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Steroid hormones and neurosteroids in normal and pathological aging of the nervous system
In Alzheimer's patients, there was a general trend toward lower levels of neurosteroids in different brain regions, and neurosteroid levels were negatively correlated with two biochemical markers of Alzheimer's disease, the phosphorylated tau protein and the beta-amyloid peptides. Expand
Comparison of plasma and cerebrospinal fluid levels of neuroactive steroids with their brain, spinal cord and peripheral nerve levels in male and female rats
The levels of some neuroactive steroids in cerebrospinal fluid as well as in plasma may be valuable to predict their levels in the nervous system, and some steroids showed a full correlation with tissue levels. Expand
Ligand for Translocator Protein Reverses Pathology in a Mouse Model of Alzheimer's Disease
TSPO is a promising target for the development of pleiotropic treatment strategies for the management of AD, and Ro5-4864 treatment effectively attenuated development of neuropathology and behavioral impairment in young-adult mice but also reversed these indices in aged 3xTgAD mice. Expand
Glia-neuron crosstalk in the neuroprotective mechanisms of sex steroid hormones
Proteins involved in the intramitochondrial trafficking of cholesterol, the first step in steroidogenesis, are upregulated in the nervous system after injury, and a local increase in the levels of steroids is observed following traumatic injury in the brain and spinal cord. Expand
Steroids and glial cell function
Hormonal and locally produced steroids act in the nervous system as neuroendocrine regulators, as trophic factors and as neuromodulators and have a major impact on neural development and function.Expand
Progesterone and its derivatives are neuroprotective agents in experimental diabetic neuropathy: A multimodal analysis
Chronic treatment with progesterone, dihydroprogesterone or its derivatives, DHP and THP, counteracted the impairment of nerve conduction velocity and thermal threshold, restored skin innervation density, and improved Na(+),K(+)-ATPase activity and mRNA levels of myelin proteins, suggesting that these neuroactive steroids, might be useful protective agents in diabetic neuropathy. Expand
Progesterone derivatives are able to influence peripheral myelin protein 22 and P0 gene expression: Possible mechanisms of action
The data obtained indicate that tetrahydroprogesterone is able to stimulate the gene expression of peripheral myelin protein 22 both in vivo (in adult but not in old animals) and in Schwann cell cultures. Expand
Steroid binding and metabolism in the luteinizing hormone-releasing hormone-producing neuronal cell line GT1-1.
GT1-1 cells possess several elements of the machinery through which sex steroids may influence LHRH dynamics, including high affinity, low capacity binding sites for estrogen and androgens and a 2-fold induction of androgen-binding sites. Expand
Interactions between neuroactive steroids and reelin haploinsufficiency in Purkinje cell survival
RT-PCR analysis indicated that heterozygosity leads to a 50% reduction of reelin RNA in the cerebellum in both sexes, as expected, and that 17beta-E upregulates reelin mRNA, particularly in rl/+ males; reelinRNA upregulation is associated with an increase of all major reelin isoforms. Expand
Patients treated for male pattern hair with finasteride show, after discontinuation of the drug, altered levels of neuroactive steroids in cerebrospinal fluid and plasma
Observations performed in a subset of patients treated for male pattern hair loss indicate that persistent sexual side effects as well as anxious/depressive symptomatology have been reported evenExpand