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Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members.
TLDR
The relative activities and the major substrates of human steroid-metabolizing UGT2B enzymes, which are expressed in a wide variety of steroid target tissues, are clearly demonstrated. Expand
Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure.
TLDR
The CLIF-C ACLFs is a clinically relevant, validated scoring system that can be used sequentially to stratify the risk of mortality in ACLF patients and is superior to the MELDs and MELD-Nas in predicting mortality. Expand
Prospective evaluation of the prognostic scores for cirrhotic patients admitted to an intensive care unit.
TLDR
For cirrhotic patients admitted to the ICU, SAPS II, and SOFA scores predicted ICU mortality better than liver-specific scores and statistical analysis showed that the prognostic severity scores, organ replacement therapy, and infection were accurate predictors of mortality. Expand
The Impact of UGT1A8, UGT1A9, and UGT2B7 Genetic Polymorphisms on the Pharmacokinetic Profile of Mycophenolic Acid After a Single Oral Dose in Healthy Volunteers
TLDR
After a single oral dose of MMF in healthy volunteers, specific UGT genotypes significantly alter MPA PKs and this clearly warrants additional studies with complete and detailed genetic profiling of UGT 1A8, UGT1A9, and UGT2B7 genes. Expand
Isolation and characterization of UGT2B15(Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene.
TLDR
Specific reverse transcriptase (RT)-PCR analysis revealed expression of the UGT2B15 gene in a wide range of extrahepatic tissues including the human liver, kidney, testis, mammary gland, placenta, adipose, skin, uterus, prostate and lung, indicating that it is a major glucuronidation enzyme in humans. Expand
Isolation and Characterization of a Novel cDNA Encoding a Human UDP-Glucuronosyltransferase Active on C19 Steroids*
TLDR
UGT2B17 is the first human uridine diphosphoglucuronosyltransferase enzyme expressed in extrahepatic tissues to have a specificity for ADT as well as testosterone, dihydrotestosterone, and 3α-diol. Expand
UGT genomic diversity: beyond gene duplication
TLDR
Novel molecular aspects that may be determinant to UGT phenotypes are discussed, including copy-number variations, epigenetic factors, and newly discovered splicing mechanisms. Expand
Pharmacogenomics of Human Uridine Diphospho‐Glucuronosyltransferases and Clinical Implications
TLDR
Interindividual variability in UGT pathways is significant and may have profound pharmacological and toxicological implications in relation to drug metabolism and diseases such as cancer. Expand
Genetic diversity at the UGT1 locus is amplified by a novel 3′ alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity
TLDR
A novel alternative splicing mechanism is revealed at the 3′ end of the UGT1 locus that further increases the number of proteins derived from this single gene, revealing a new regulatory mechanism of the glucuronidation pathway. Expand
Current use and perspective of indocyanine green clearance in liver diseases.
TLDR
Clinical evidence suggests that the ICG retention test can enable the establishment of tailored management strategies by providing prognostic information, and this parameter is an attractive addition to liver function and regional haemodynamic monitoring. Expand
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