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SPO11 gene

Known as: TOPOISOMERASE VI-A, spermatogenesis associated 43, cancer/testis antigen 35 
This gene plays a role in meiotic recombination and centromere association.
National Institutes of Health

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Related topics

6 relations
Ligand BindingMeiotic RecombinationOogenesisSPO11 protein, human

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SPO11 wt Allele

Papers overview

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2013
2013
Meiotic Cohesin SMC1β Provides Prophase I Centromeric Cohesion and Is Required for Multiple Synapsis-Associated Functions
Cohesin subunit SMC1β is specific and essential for meiosis. Previous studies showed functions of SMC1β in determining the axis… 
2012
2012
Suberoylanilide hydroxamic acid affects γH2AX expression in osteosarcoma, atypical teratoid rhabdoid tumor and normal tissue cell lines after irradiation
PurposeOsteosarcoma and atypical teratoid rhabdoid tumors are tumor entities with varying response to common standard therapy… 
2011
2011
DNA Sequence-Mediated, Evolutionarily Rapid Redistribution of Meiotic Recombination Hotspots
Hotspots regulate the position and frequency of Spo11 (Rec12)-initiated meiotic recombination, but paradoxically they are… 
2007
2007
Targeted induction of meiotic double-strand breaks reveals chromosomal domain-dependent regulation of Spo11 and interactions among potential sites of meiotic recombination
Meiotic recombination is initiated by programmed DNA double-strand break (DSB) formation mediated by Spo11. DSBs occur with… 
Highly Cited
2004
Highly Cited
2004
The structure of Ski8p, a protein regulating mRNA degradation: Implications for WD protein structure
Ski8p is a 44‐kD protein that primarily functions in the regulation of exosome‐mediated, 3′→ 5′ degradation of damaged mRNA. It… 
2002
2002
Infertilit humaine: des gnes de miose comme candidats potentiels
2002
2002
Most meiotic CAG repeat tract-length alterations in yeast are SPO11 dependent
Abstract. The expansion of trinucleotide repeat sequences associated with hereditary neurological diseases is believed from… 
2000
2000
Mouse homolog of Saccharomyces cerevisiae spo11 is induced in normal mu(+)B-cells by stimuli that cause germline C(H) transcription and subsequent class switch recombination.
The first step of Ig heavy chain class switch recombination (CSR) is considered to be DNA double strand break (DSB) formation in… 
1991
1991
Allelic and ectopic interactions in recombination-defective yeast strains.
Ectopic recombination in the yeast Saccharomyces cerevisiae has been investigated by examining the effects of mutations known to… 
Highly Cited
1984
Highly Cited
1984
Relationships between a hyper-rec mutation (REM1) and other recombination and repair genes in yeast.
Mutations in the REM1 gene of Saccharomyces cerevisiae confer a semidominant hyper-recombination and hypermutable phenotype upon… 
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