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SPO11 gene

Known as: TOPOISOMERASE VI-A, spermatogenesis associated 43, cancer/testis antigen 35 
This gene plays a role in meiotic recombination and centromere association.
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
A partner protein for meiotic snip Eukaryotes generate germ cells through meiotic recombination. This process initiates through… Expand
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Highly Cited
2013
Highly Cited
2013
Different organisms display widely different numbers of the programmed double-strand breaks (DSBs) that initiate meiotic… Expand
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Highly Cited
2008
Highly Cited
2008
The synaptonemal complex (SC), a tripartite proteinaceous structure that forms between homologous chromosomes during meiosis, is… Expand
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Highly Cited
2006
Highly Cited
2006
The Spo11 protein is a eukaryotic homologue of the archaeal DNA topoisomerase VIA subunit (topo VIA). In archaea it is involved… Expand
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Highly Cited
2005
Highly Cited
2005
SPO11 introduces double-strand breaks (DSBs) that trigger the phosphorylation of H2AX during meiotic prophase. In mice, SPO11 is… Expand
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Highly Cited
2005
Highly Cited
2005
Repair of DNA double strand breaks (DSBs) by the non-homologous end joining (NHEJ) pathway in mammals requires at least the DNA… Expand
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Highly Cited
2000
Highly Cited
2000
The Spo11 protein initiates meiotic recombination by generating DNA double-strand breaks (DSBs) and is required for meiotic… Expand
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Highly Cited
2000
Highly Cited
2000
Spo11, a protein first identified in yeast, is thought to generate the chromosome breaks that initiate meiotic recombination. We… Expand
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Highly Cited
1998
Highly Cited
1998
Meiotic recombination requires the action of several gene products in both Saccharomyces cerevisiae and Drosophila melanogaster… Expand
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Highly Cited
1995
Highly Cited
1995
We describe the identification of a new meiosis-specific gene of Saccharomyces cerevisiae, NDT80. The ndt80 null and point… Expand
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