SPO11 gene

Known as: TOPOISOMERASE VI-A, spermatogenesis associated 43, cancer/testis antigen 35 
This gene plays a role in meiotic recombination and centromere association.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1985-2018
012319852018

Papers overview

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2013
2013
In mammalian meiotic prophase, the initial steps in repair of SPO11-induced DNA double-strand breaks (DSBs) are required to… (More)
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2013
2013
Spo11 is the topoisomerase-like enzyme responsible for the induction of the meiosis-specific double strand breaks (DSBs), which… (More)
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2007
2007
SPO11, a homolog of the subunit A of the archaebacterial topoisomerase VI, is essential for double-strand break (DSB)-induced… (More)
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2006
2006
Some organisms, such as mammals, green plants and fungi, require double-strand breaks in DNA (DSBs) for synapsis of homologous… (More)
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Highly Cited
2005
Highly Cited
2005
SPO11 introduces double-strand breaks (DSBs) that trigger the phosphorylation of H2AX during meiotic prophase. In mice, SPO11 is… (More)
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2002
2002
In Saccharomyces cerevisiae, formation of the DNA double-strand breaks (DSBs) that initiate meiotic recombination requires the… (More)
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Highly Cited
2001
Highly Cited
2001
The Saccharomyces cerevisiae Spo11 protein catalyses DNA double-strand breaks (DSBs) that initiate meiotic recombination. The… (More)
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2000
2000
The Spo11 protein of yeast has been found to be covalently bound to double-strand breaks in meiosis, demonstrating a unique role… (More)
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1987
1987
The SPO11 gene, required for meiotic recombination in Saccharomyces cerevisiae, has been cloned by direct selection for… (More)
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1985
1985
Several complementary experimental approaches were used to demonstrate that the SPO11 gene is specifically required for meiotic… (More)
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