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SORL1 protein, human

Known as: sortilin-related receptor, L(DLR class) A repeats-containing, human, LR11, SorLA-1 protein, human 
Sortilin-related receptor (2214 aa, ~248 kDa) is encoded by the human SORL1 gene. This protein is involved in both endocytosis and protein… 
National Institutes of Health

Related topics

Related topics

13 relations
Cellular MembraneEGF-Like DomainIntegral Membrane ProteinsLigand Binding

Broader (1)

Membrane Transport Proteins

Papers overview

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Review
2013
Review
2013
Sorting receptor SORLA – a trafficking path to avoid Alzheimer disease
Summary Excessive proteolytic breakdown of the amyloid precursor protein (APP) to neurotoxic amyloid &bgr; peptides (A&bgr;) by… 
Highly Cited
2011
Highly Cited
2011
BACE1 Retrograde Trafficking Is Uniquely Regulated by the Cytoplasmic Domain of Sortilin*
BACE1 (β-site β-amyloid precursor protein (APP)-cleaving enzyme 1) mediates the first proteolytic cleavage of APP, leading to… 
Highly Cited
2011
Highly Cited
2011
In situ structural characterization of a recombinant protein in native Escherichia coli membranes with solid-state magic-angle-spinning NMR.
The feasibility of using solid-state magic-angle-spinning NMR spectroscopy for in situ structural characterization of the LR11… 
Highly Cited
2010
Highly Cited
2010
Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated
BackgroundRetrograde transport of several transmembrane proteins from endosomes to the trans-Golgi network (TGN) occurs via Rab 5… 
Highly Cited
2009
Highly Cited
2009
Brain-Derived Neurotrophic Factor Reduces Amyloidogenic Processing through Control of SORLA Gene Expression
Sorting protein-related receptor with A-type repeats (SORLA) is a major risk factor in cellular processes leading to Alzheimer's… 
Highly Cited
2008
Highly Cited
2008
Sortilin-related Receptor with A-type Repeats (SORLA) Affects the Amyloid Precursor Protein-dependent Stimulation of ERK Signaling and Adult Neurogenesis*
Sortilin-related receptor with A-type repeats (SORLA) is a sorting receptor that impairs processing of amyloid precursor protein… 
Highly Cited
2007
Highly Cited
2007
Wheat leaf and stem rust in the United States
Leaf rust, caused by Puccinia triticina, is a common and widespread disease of wheat in the US. On an annual basis, over 50 races… 
Highly Cited
2006
Highly Cited
2006
LR11/SorLA Expression Is Reduced in Sporadic Alzheimer Disease but not in Familial Alzheimer Disease
LR11 is an ApoE receptor that is enriched in the brain. We have shown that LR11 is markedly downregulated in patients with… 
Highly Cited
2006
Highly Cited
2006
Interaction of the Cytosolic Domains of sorLA/LR11 with the Amyloid Precursor Protein (APP) and β-Secretase β-Site APP-Cleaving Enzyme
sorLA is a recently identified neuronal receptor for amyloid precursor protein (APP) that is known to interact with APP and… 
Highly Cited
2002
Highly Cited
2002
The sorLA cytoplasmic domain interacts with GGA1 and ‐2 and defines minimum requirements for GGA binding
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