Variant of TREM2 associated with the risk of Alzheimer's disease.
- T. Jónsson, H. Stefánsson, K. Stefánsson
- BiologyNew England Journal of Medicine
- 9 January 2013
These findings strongly implicate variant TREM2 in the pathogenesis of Alzheimer's disease and find that carriers of rs75932628-T between the ages of 80 and 100 years without Alzheimer’s disease had poorer cognitive function than noncarriers.
Localization of neuronal and glial glutamate transporters
- J. Rothstein, L. Martin, R. Kuncl
- BiologyNeuron
- 1 September 1994
Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (Substantia innominata), and hypothalamus in…
- M. Mesulam, E. Mufson, A. Levey, B. Wainer
- BiologyThe Journal of comparative neurology
- 20 February 1983
The organization of projections from the cholinergic neurons of the basal forebrain to neocortex and associated structures was investigated in the rhesus monkey with the help of horseradish…
Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1–Ch6)
- M. Mesulam, E. Mufson, B. Wainer, A. Levey
- BiologyNeuroscience
- 1 December 1983
Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis
- J. Rothstein, M. van Kammen, A. Levey, L. Martin, R. Kuncl
- BiologyAnnals of Neurology
- 1 July 1995
Developing C‐terminal, antioligopeptide antibodies that were specific for each glutamate transporter subtype found that GLT‐1 immunoreactive protein was severely decreased in ALS, both in motor cortex (71% decrease compared with control) and in spinal cord.
Vitamin E and donepezil for the treatment of mild cognitive impairment.
- R. Petersen, Ronald G. Thomas, L. Thal
- Medicine, PsychologyNew England Journal of Medicine
- 9 June 2005
Vitamin E had no benefit in patients with mild cognitive impairment and donepezil therapy was associated with a lower rate of progression to Alzheimer's disease during the first 12 months of treatment, a finding supported by the secondary outcome measures.
Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo
- D. Borchelt, G. Thinakaran, S. Sisodia
- BiologyNeuron
- 1 November 1996
Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease
- A. Naj, G. Jun, G. Schellenberg
- BiologyNature Genetics
- 3 April 2011
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and two…
Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo
- G. Thinakaran, D. Borchelt, S. Sisodia
- BiologyNeuron
- 1 July 1996
A common variant on chromosome 9p21 affects the risk of myocardial infarction.
- A. Helgadóttir, G. Thorleifsson, K. Stefánsson
- Biology, MedicineScience
- 1 September 2007
An association between myocardial infarction and a common sequence variant on chromosome 9p21 was associated with the disease with high significance and approximately 21% of individuals in the population are homozygous for this variant, and their estimated risk of suffering myocardious disease is 1.64 times as great as that of noncarriers.
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