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- Publications
- Influence
Office of Rare Diseases Neuropathologic Criteria for Corticobasal Degeneration
- D. Dickson, C. Bergeron, +11 authors I. Litvan
- Psychology, Medicine
- Journal of neuropathology and experimental…
- 1 November 2002
A working group supported by the Office of Rare Diseases of the National Institutes of Health formulated neuropathologic criteria for corticobasal degeneration (CBD) that were subsequently validated… Expand
Diagnosis and management of dementia with Lewy bodies
- I. McKeith, B. Boeve, +60 authors K. Kosaka
- Medicine
- Neurology
- 4 July 2017
The Dementia with Lewy Bodies (DLB) Consortium has refined its recommendations about the clinical and pathologic diagnosis of DLB, updating the previous report, which has been in widespread use for… Expand
TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease
- S. Rayaprolu, Bianca Mullen, +30 authors O. A. Ross
- Medicine
- Molecular Neurodegeneration
- 21 June 2013
BackgroundA rare variant in the Triggering Receptor Expressed on Myeloid cells 2 (TREM2) gene has been reported to be a genetic risk factor for Alzheimer’s disease by two independent groups (Odds… Expand
Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease
- Y. Vodovotz, M. S. Lucia, +10 authors M. Sporn
- Biology, Medicine
- The Journal of experimental medicine
- 1 October 1996
In Alzheimer's disease (AD), affected neurons accumulate beta amyloid protein, components of which can induce mouse microglia to express the high-output isoform of nitric oxide synthase (NOS2) in… Expand
DLB and PDD boundary issues
- C. Lippa, J. Duda, +29 authors Z. Wszolek
- Medicine
- Neurology
- 13 March 2007
For more than a decade, researchers have refined criteria for the diagnosis of dementia with Lewy bodies (DLB) and at the same time have recognized that cognitive impairment and dementia occur… Expand
Amyloid Deposition Begins in the Striatum of Presenilin-1 Mutation Carriers from Two Unrelated Pedigrees
- W. Klunk, J. Price, +18 authors S. Dekosky
- Medicine
- The Journal of Neuroscience
- 6 June 2007
The amyloid cascade hypothesis suggests that the aggregation and deposition of amyloid-β protein is an initiating event in Alzheimer's disease (AD). Using amyloid imaging technology, such as the… Expand
Transforming growth factor-betas in neurodegenerative disease.
- K. Flanders, R. F. Ren, C. Lippa
- Biology, Medicine
- Progress in neurobiology
- 1998
Transforming growth factors-betas (TGF-betas), a family of multifunctional peptide growth factors, affect cells of the central nervous system (CNS). The three mammalian TGF-beta isoforms, TGF-betas… Expand
TRANSFORMING GROWTH FACTOR-βS IN NEURODEGENERATIVE DISEASE
- K. Flanders, R. F. Ren, C. Lippa
- Biology
- Progress in Neurobiology
- 31 January 1998
Abstract Transforming growth factors- β s (TGF- β s), a family of multifunctional peptide growth factors, affect cells of the central nervous system (CNS). The three mammalian TGF- β isoforms, TGF- β… Expand
Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases.
- G. Coppola, Subashchandrabose Chinnathambi, +71 authors D. Geschwind
- Biology, Medicine
- Human molecular genetics
- 1 August 2012
Rare mutations in the gene encoding for tau (MAPT, microtubule-associated protein tau) cause frontotemporal dementia-spectrum (FTD-s) disorders, including FTD, progressive supranuclear palsy (PSP)… Expand
LR11/SorLA Expression Is Reduced in Sporadic Alzheimer Disease but not in Familial Alzheimer Disease
- Sara E. Dodson, M. Gearing, C. Lippa, T. Montine, A. Levey, J. Lah
- Biology, Medicine
- Journal of neuropathology and experimental…
- 1 September 2006
LR11 is an ApoE receptor that is enriched in the brain. We have shown that LR11 is markedly downregulated in patients with sporadic Alzheimer disease (AD). This finding led us to explore whether… Expand