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SNCA wt Allele

Known as: PD1, NACP, PARK1 
Human SNCA wild-type allele is located in the vicinity of 4q21 and is approximately 111 kb in length. This allele, which encodes alpha-synuclein… 
National Institutes of Health

Related topics

Related topics

15 relations
4q21Alzheimer's DiseaseAlzheimer's Disease Pathway KEGGApoptosis

Broader (1)

SNCA gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Antibacterial Nanocomposite with Calcium Phosphate and Quaternary Ammonium
Secondary caries is a frequent reason for restoration failure, resulting from acidogenic bacteria and their biofilms. The… 
Highly Cited
2008
Highly Cited
2008
Superoxide dismutase overexpression protects dopaminergic neurons in a Drosophila model of Parkinson's disease
Review
2001
Review
2001
Ubiquinone (Coenzyme Q10) and Mitochondria in Oxidative Stress of Parkinson’s Disease
Parkinson’s disease is the second most common neurodegenerative disorder after Alzheimer’s disease affecting approximately1% of… 
Review
2001
Review
2001
From genetics to pathology: tau and alpha-synuclein assemblies in neurodegenerative diseases.
The most common degenerative diseases of the human brain are characterized by the presence of abnormal filamentous inclusions in… 
2001
2001
Biochemical Analysis of Cybrids Expressing Mitochondrial DNA from Contursi Kindred Parkinson's Subjects
Complex I activity is reduced in cytoplasmic hybrid (cybrid) cell lines that contain mitochondrial DNA (mtDNA) from sporadic… 
Review
2000
Review
2000
Involvement of alpha-synuclein in Parkinson's disease and other neurodegenerative disorders.
A major step in the elucidation of the pathogenesis of neurodegenerative disorders was the identification of a mutation in the… 
Highly Cited
1999
Highly Cited
1999
Mutated alpha-synuclein gene in two Greek kindreds with familial PD: incomplete penetrance?
The G209A mutation in the alpha-synuclein gene has been associated with autosomal dominant PD (ADPD) in a family from Contursi… 
Highly Cited
1998
Highly Cited
1998
The α‐synuclein Ala53Thr mutation is not a common cause of familial Parkinson's disease: A study of 230 European cases
We report the results of a screen of 230 European familial index cases of Parkinson's disease for the recently described Ala53Thr… 
1998
1998
The alpha-synuclein Ala53Thr mutation is not a common cause of familial Parkinson's disease: a study of 230 European cases. European Consortium on Genetic Susceptibility in Parkinson's Disease.
We report the results of a screen of 230 European familial index cases of Parkinson's disease for the recently described Ala53Thr… 
Highly Cited
1997
Highly Cited
1997
Identification of Spanish familial Parkinson's disease and screening for the Ala53Thr mutation of the α-synuclein gene in early onset patients
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