SNCA wt Allele

Known as: PD1, NACP, PARK1 
Human SNCA wild-type allele is located in the vicinity of 4q21 and is approximately 111 kb in length. This allele, which encodes alpha-synuclein… (More)
National Institutes of Health

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Highly Cited
2008
Highly Cited
2008
BACKGROUND Alpha-synuclein has been directly linked to Parkinson's disease etiology by mutations in and multiplication of its… (More)
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Highly Cited
2008
Highly Cited
2008
Mutations or multiplications in alpha-synuclein gene cause familial forms of Parkinson disease or dementia with Lewy bodies (LB… (More)
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Highly Cited
2006
Highly Cited
2006
OBJECTIVE Recently, genomic multiplications of alpha-synuclein gene (SNCA) have been reported to cause hereditary early-onset… (More)
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Highly Cited
2004
Highly Cited
2004
The alpha-synuclein gene (SNCA) has been implicated in autosomal dominant forms of Parkinson's disease. We screened 119… (More)
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Highly Cited
2003
Highly Cited
2003
Alpha-synuclein was implicated in Parkinson's disease when missense mutations in the alpha-synuclein gene were found in autosomal… (More)
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Highly Cited
2002
Highly Cited
2002
The deposition of the abundant presynaptic brain protein alpha-synuclein as fibrillary aggregates in neurons or glial cells is a… (More)
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Highly Cited
2002
Highly Cited
2002
alpha-Synuclein is a major component of the fibrillary lesion known as Lewy bodies and Lewy neurites that are the pathologic… (More)
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Highly Cited
2001
Highly Cited
2001
Mutations in the alpha-synuclein gene (SNCA) have been implicated in familial Parkinson's disease (PD) while certain polymorphic… (More)
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Highly Cited
2001
Highly Cited
2001
We describe an Australian family of Greek origin with a parkinsonian syndrome and an Ala53Thr alpha-synuclein gene mutation. Five… (More)
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Highly Cited
1997
Highly Cited
1997
Parkinson's disease (PD) is a common neurodegenerative disorder with a lifetime incidence of approximately 2 percent. A pattern… (More)
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