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Elevation of total homocysteine levels in patients with Parkinson’s disease treated with duodenal levodopa/carbidopa gel
Levodopa/carbidopa (LD/CD) application elevates total plasma homocysteine (thcys). We determined thcys-, LD- and 3-O-methyldopa (3-OMD) concentrations in 28 patients with Parkinson’s disease (PD) onExpand
Experience Double Chooz : simulation des spectres antineutrinos issus de reacteurs
L’experience Double Chooz a pour but d’etudier les oscillations des antineutrinos electroniques produits par la centrale nucleaire de Chooz, situee en France, dans la region des Ardennes. ElleExpand
Serum levels of neuron-specific enolase and s-100 protein after single tonic-clonic seizures
Abstract Serum neuron-specific enolase (s-NSE) and s-100 protein (s-100) are sensitive markers of various brain diseases. We investigated both of these markers in nine patients within 5 min, 6 h, 12Expand
Increased MS relapse rate during assisted reproduction technique
Sirs: Fifteen percent of all women suffer from infertility, but fertility is not reduced in patients with multiple sclerosis (MS) [3]. Infertile women may use routine hormonal stimulation in theExpand
Malnutritional neuropathy under intestinal levodopa infusion
Levodopa/Carbidopa intestinal gel infusion (LCIG) for Parkinson’s disease is under debate to provoke polyneuropathy (PNP). In our cohort of 20 thus treated patients, two developed debilitating axonalExpand
Pilot study: peripheral biomarkers for diagnosing sporadic Parkinson’s disease
The need for an early and differential diagnosis of Parkinson’s disease (PD) is undoubtedly one of the main quests of the century. An early biomarker would enable therapy to begin sooner and would,Expand
Pharmacokinetic behaviour of levodopa and 3-O-methyldopa after repeat administration of levodopa/carbidopa with and without entacapone in patients with Parkinson’s disease
Summary.Addition of the catechol-O-methyltransferase (COMT) inhibitor entacapone (EN) prolongs plasma metabolism of levodopa (LD). Objectives were to determine the clinical response after EN additionExpand
Involvement of α-synuclein in Parkinson's disease and other neurodegenerative disorders
Summary. A major step in the elucidation of the pathogenesis of neurodegenerative disorders was the identification of a mutation in the α-synuclein gene in autosomal dominant Parkinson's diseaseExpand
Error processing in patients with Parkinson’s disease: the influence of medication state
Summary.One of the hallmarks of Parkinson’s disease (PD) is a depletion of dopamine. Error processing, as reflected in a component of the event-related potential, the so-called error (related)Expand
Parkin gene variations in late‐onset Parkinson's disease: comparison between Norwegian and German cohorts
Objectives –  Mutations in the Parkin gene can cause autosomal recessive early‐onset Parkinson's disease (PD). Recently, Parkin mutations were also suggested to play a role in the commoner late‐onsetExpand