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- Publications
- Influence
Alpha-synuclein in Lewy bodies.
- M. Spillantini, M. L. Schmidt, V. Lee, J. Trojanowski, R. Jakes, M. Goedert
- Medicine
- Nature
- 1997
α-Synuclein in Lewy bodies
- M. Spillantini, M. L. Schmidt, V. Lee, J. Trojanowski, R. Jakes, M. Goedert
- Biology
- Nature
- 28 August 1997
Lewy bodies, a defining pathological characteristic of Parkinson's disease and dementia with Lewy bodies (DLB), constitute the second most common nerve cell pathology, after the neurofibrillary… Expand
Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease
- M. Goedert, M. Spillantini, R. Jakes, D. Rutherford, R. Crowther
- Biology, Medicine
- Neuron
- 1 October 1989
We have determined the sequences of isoforms of human tau protein, which differ from previously reported forms by insertions of 29 or 58 amino acids in the amino-terminal region. Complementary DNA… Expand
α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies
- M. Spillantini, R. Crowther, R. Jakes, M. Hasegawa, M. Goedert
- Chemistry
- 26 May 1998
Lewy bodies and Lewy neurites are the defining neuropathological characteristics of Parkinson’s disease and dementia with Lewy bodies. They are made of abnormal filamentous assemblies of unknown… Expand
Mutation in the tau gene in familial multiple system tauopathy with presenile dementia.
- M. Spillantini, J. Murrell, M. Goedert, M. Farlow, A. Klug, B. Ghetti
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 23 June 1998
Familial multiple system tauopathy with presenile dementia (MSTD) is a neurodegenerative disease with an abundant filamentous tau protein pathology. It belongs to the group of familial frontotemporal… Expand
Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia
- G. Skibinski, N. Parkinson, +16 authors J. Collinge
- Biology, Medicine
- Nature Genetics
- 24 July 2005
We have previously reported a large Danish pedigree with autosomal dominant frontotemporal dementia (FTD) linked to chromosome 3 (FTD3). Here we identify a mutation in CHMP2B, encoding a component of… Expand
alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies.
- M. Spillantini, R. Crowther, R. Jakes, M. Hasegawa, M. Goedert
- Medicine
- Proceedings of the National Academy of Sciences…
- 1998
Lewy bodies and Lewy neurites are the defining neuropathological characteristics of Parkinson's disease and dementia with Lewy bodies. They are made of abnormal filamentous assemblies of unknown… Expand
A Century of Alzheimer's Disease
- M. Goedert, M. Spillantini
- Biology, Medicine
- Science
- 3 November 2006
One hundred years ago a small group of psychiatrists described the abnormal protein deposits in the brain that define the most common neurodegenerative diseases. Over the past 25 years, it has become… Expand
Identification of two distinct synucleins from human brain
- R. Jakes, M. Spillantini, M. Goedert
- Biology, Medicine
- FEBS letters
- 23 May 1994
Two abundant proteins of 140 and 134 amino acids were purified and sequenced from human brain. They were identified through their reactivity on immunoblots with a partially characterised monoclonal… Expand
Cloning and sequencing of the cDNA encoding an isoform of microtubule‐associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.
- M. Goedert, M. Spillantini, M. Potier, J. Ulrich, R. Crowther
- Biology, Medicine
- The EMBO journal
- 1 February 1989
We have isolated cDNA clones encoding a 383‐amino acid isoform of the human microtubule‐associated protein tau. It differs from previously determined tau sequences by the presence of an additional… Expand
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