• Publications
  • Influence
α-Synuclein in Lewy bodies
TLDR
Strong staining of Lewy bodies from idiopathic Parkinson's disease with antibodies for α-synuclein, a presynaptic protein of unknown function which is mutated in some familial cases of the disease, indicates that the LewY bodies from these two diseases may have identical compositions.
α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies
TLDR
It is shown thatLewy bodies and Lewy neurites from Parkinson’s disease and dementia with Lewy bodies are stained strongly by antibodies directed against amino- terminal and carboxyl-terminal sequences of α-synuclein, showing the presence of full- length or close to full-length α- synuclein.
Mutation in the tau gene in familial multiple system tauopathy with presenile dementia.
TLDR
The results show that dysregulation of tau protein production can cause neurodegeneration and imply that the FTDP-17 gene is the tau gene, which has major implications for Alzheimer's disease and other tauopathies.
Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia
TLDR
A mutation in CHMP2B, encoding a component of the endosomal ESCRTIII complex, is identified and it is shown that it results in aberrant mRNA splicing in tissue samples from affected members of this family.
A Century of Alzheimer's Disease
TLDR
The ongoing molecular dissection of the neurodegenerative pathways is expected to lead to a true understanding of disease pathogenesis.
alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies.
TLDR
It is shown thatLewy bodies and Lewy neurites from Parkinson's disease and dementia with Lewy bodies are stained strongly by antibodies directed against amino- terminal and carboxyl-terminal sequences of alpha-synuclein, showing the presence of full- length or close to full-length alpha- synuclein.
Cloning and sequencing of the cDNA encoding an isoform of microtubule‐associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.
TLDR
Tau protein is found in the protease‐resistant core of the paired helical filament, the major constituent of the neurofibrillary tangle in Alzheimer's disease.
...
1
2
3
4
5
...