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SLC1A2 wt Allele

Known as: Excitotoxic Amino Acid Transporter 2 Gene, GLT-1, Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 wt Allele 
Human SLC1A2 wild-type allele is located within 11p13-p12 and is approximately 169 kb in length. This allele, which encodes excitatory amino acid… 
National Institutes of Health

Related topics

Related topics

8 relations
11p13-p12Amyotrophic Lateral SclerosisHomo sapiensLigand Binding

Broader (1)

SLC1A2 gene

Papers overview

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Highly Cited
2013
Highly Cited
2013
Neuronal Exosomal miRNA-dependent Translational Regulation of Astroglial Glutamate Transporter GLT1*
Background: Pathways involved in neuron-dependent GLT1 regulation in astrocytes remain to be characterized. Results: Neuronal… 
Highly Cited
2010
Highly Cited
2010
Ceftriaxone Restores Glutamate Homeostasis and Prevents Relapse to Cocaine Seeking
Highly Cited
2004
Highly Cited
2004
Loss of glutamine synthetase in the human epileptogenic hippocampus: possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsy
Highly Cited
2001
Highly Cited
2001
The glial glutamate transporter, GLT‐1, is oxidatively modified by 4‐hydroxy‐2‐nonenal in the Alzheimer's disease brain: the role of Aβ1–42
Glutamate transporters are involved in the maintenance of synaptic glutamate concentrations. Because of its potential… 
Highly Cited
2001
Highly Cited
2001
Histological Evidence of Protein Aggregation in Mutant SOD1 Transgenic Mice and in Amyotrophic Lateral Sclerosis Neural Tissues
The mechanisms leading to neurodegeneration in ALS (amyotrophic lateral sclerosis) are not well understood, but cytosolic protein… 
Highly Cited
1999
Highly Cited
1999
Compromised Glutamate Transport in Human Glioma Cells: Reduction–Mislocalization of Sodium-Dependent Glutamate Transporters and Enhanced Activity of Cystine–Glutamate Exchange
Elevated levels of extracellular glutamate ([Glu]o) can induce seizures and cause excitotoxic neuronal cell death. This is… 
Highly Cited
1999
Highly Cited
1999
Glutamate Induces Rapid Upregulation of Astrocyte Glutamate Transport and Cell-Surface Expression of GLAST
Glutamate transporters clear glutamate from the extracellular space by high-affinity binding and uptake. Factors that regulate… 
Review
1998
Review
1998
Molecular biology of mammalian plasma membrane amino acid transporters.
Molecular biology entered the field of mammalian amino acid transporters in 1990-1991 with the cloning of the first GABA and… 
Highly Cited
1998
Highly Cited
1998
The Number of Glutamate Transporter Subtype Molecules at Glutamatergic Synapses: Chemical and Stereological Quantification in Young Adult Rat Brain
The role of transporters in shaping the glutamate concentration in the extracellular space after synaptic release is… 
Highly Cited
1997
Highly Cited
1997
Glutamate Transporter Protein Subtypes Are Expressed Differentially during Rat CNS Development
Extracellular glutamate concentrations are regulated by glial and neuronal transporter proteins. Four glutamate transporter… 
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