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Cloning and expression of a rat brain L-glutamate transporter
TLDR
An antibody against a glial L-glutamate transporter from rat brain is used to isolate a complemen-tary DNA clone encoding this transporter, which predicts a protein of 573 amino acids with 8–9 putative transmembrane α-helices that seems to be a member of a new family of transport molecules.
Cloning and expression of a rat brain GABA transporter.
TLDR
Hydropathy analysis of the deduced protein suggests multiple transmembrane regions, a feature shared by several cloned transporters; however, database searches indicate that GAT-1 is not homologous to any previously identified proteins.
Ion Binding and Permeation at the GABA Transporter GAT1
TLDR
The hypothesis that efficient removal of synaptic transmitter by the GABA transporter GAT1 depends on the previous binding of Na+ and Cl− is supported, and the important role of the conserved putative transmembrane domain 1 in interactions with the permeant substrates is indicated.
Mechanism of chloride interaction with neurotransmitter:sodium symporters
TLDR
The data indicate that the negative charge, provided either by chloride or by the transporter itself, is required during binding and translocation of the neurotransmitter, probably to counterbalance the charge of the co-transported sodium ions.
Arginine 447 Plays a Pivotal Role in Substrate Interactions in a Neuronal Glutamate Transporter*
TLDR
Arginine 447 plays a pivotal role in the sequential interaction of acidic amino acids and potassium with the transporter and, thereby, constitutes one of the molecular determinants of coupling their fluxes.
Mechanism of transport and storage of neurotransmitters.
TLDR
This review will focus on the bioenergetics, mechanism, and molecular basis of neurotransmitter transport, and the sodium-coupled and proton coupled systems, which play an important role in the overall process of synaptic transmission.
An [Na+ + K+]coupledl-glutamate transporter purified from rat brain is located in glial cell processes
Polyclonal antibodies were generated against the major polypeptide (73,000 mol. wt) present in a highly purified preparation of the [Na+ + K+]coupled L-glutamate transporter from rat brain. These
Cloning and expression of a rat brain L-glutamate transporter
Nature 360, 464-467 (1992) THE third author's name was shown incorrectly in this letter. It should read Magnar Bj0ras, as above. In addition, Fig. 2b is not, as stated, a western blot but is an
Mechanism of Transport and Storage of Neurotransmitter
This review will focus on the bioenergetics, mechanism, and molecular basis of neurotransmitter transport. As indicated in the next section, these processes play an important role in the overall
Phosphorylation and modulation of brain glutamate transporters by protein kinase C.
TLDR
This report describes that the purified L-glutamate transporter from pig brain is phosphorylated by protein kinase C, predominantly at serine residues, which is the first direct demonstration of the regulation of a neurotransmitter transporter by phosphorylation.
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