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SHMT1 gene

Known as: cytoplasmic serine hydroxymethyltransferase, serine hydroxymethyltransferase 1, MGC24556 
This gene is involved in amino acid metabolism.
National Institutes of Health

Related topics

Related topics

7 relations
Amino Acid BiosynthesisGlycine HydroxymethyltransferaseMethylationNucleotide Biosynthesis

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SHMT1 wt Allele

Papers overview

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2012
2012
Serine hydroxymethyltransferase 1 and 2: gene sequence variation and functional genomic characterization
J. Neurochem. (2012) 120, 881–890. 
2010
2010
SHMT1 1420 and MTHFR 677 variants are associated with rectal but not colon cancer
BackgroundAssociation between rectal or colon cancer risk and serine hydroxymethyltransferase 1 (SHMT1) C1420T or… 
Highly Cited
2007
Highly Cited
2007
Association of MTHFR C677T and SHMT1 C1420T with susceptibility to ESCC and GCA in a high incident region of Northern China
ObjectiveTo assess the association between the C to T transition in the methylenetetrahydro folate reductase gene (MTHFR C677T… 
2005
2005
Transcriptional regulation of the one‐carbon metabolism regulon in Saccharomyces cerevisiae by Bas1p
The mechanisms mediating responses to glycine withdrawal in budding yeast were studied using a genome‐wide profiling approach. A… 
Highly Cited
2005
Highly Cited
2005
Polymorphisms in cytoplasmic serine hydroxymethyltransferase and methylenetetrahydrofolate reductase affect the risk of cardiovascular disease in men.
Genetic variation in folate-regulating enzymes contributes to the risk of cardiovascular disease (CVD). The cytoplasmic serine… 
Highly Cited
2002
Highly Cited
2002
Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia.
We previously reported that 2 polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene at positions C677T and… 
2000
2000
Mimosine Is a Cell-specific Antagonist of Folate Metabolism*
Iron deficiency and iron chelators are known to alter folate metabolism in mammals, but the underlying biochemical mechanisms… 
2000
2000
Human cytoplasmic serine hydroxymethyltransferase is an mRNA binding protein.
The 5' untranslated region (UTR) of the human cytoplasmic serine hydroxymethyltransferase (cSHMT) message is alternatively… 
Highly Cited
1998
Highly Cited
1998
Molecular cloning, characterization and alternative splicing of the human cytoplasmic serine hydroxymethyltransferase gene.
Highly Cited
1997
Highly Cited
1997
Role of mitochondrial and cytoplasmic serine hydroxymethyltransferase isozymes in de novo purine synthesis in Saccharomyces cerevisiae.
One-carbon units are essential to a variety of anabolic processes which yield necessary cellular components including purines… 
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