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SHMT1 gene

Known as: cytoplasmic serine hydroxymethyltransferase, serine hydroxymethyltransferase 1, MGC24556 
This gene is involved in amino acid metabolism.
National Institutes of Health

Papers overview

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2014
2014
Reprogramming of cellular metabolism towards de novo serine production fuels the growth of cancer cells, providing essential… Expand
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2010
2010
BackgroundAssociation between rectal or colon cancer risk and serine hydroxymethyltransferase 1 (SHMT1) C1420T or… Expand
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Highly Cited
2008
Highly Cited
2008
The hydroxymethyl group of serine is a primary source of tetrahydrofolate (THF)-activated one-carbon units that are required for… Expand
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Highly Cited
2007
Highly Cited
2007
Perturbations in folate-mediated one-carbon metabolism increase rates of uracil misincorporation into DNA during replication… Expand
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Highly Cited
2006
Highly Cited
2006
ObjectiveTo assess the association between the C to T transition in the methylenetetrahydro folate reductase gene (MTHFR C677T… Expand
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Highly Cited
2005
Highly Cited
2005
We found that a recessive mutation, shmt1-1, causes aberrant regulation of cell death resulting in chlorotic and necrotic lesion… Expand
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Highly Cited
2002
Highly Cited
2002
Folate-dependent one-carbon metabolism is required for the synthesis of purines and thymidylate and for the remethylation of… Expand
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Highly Cited
2002
Highly Cited
2002
We previously reported that 2 polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene at positions C677T and… Expand
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2000
2000
Serine hydroxymethyltransferase (SHMT) is a pyridoxal phosphate-dependent enzyme that catalyzes the reversible conversion of… Expand
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Highly Cited
1998
Highly Cited
1998
The human cytoplasmic serine hydroxymethyltransferase (CSHMT) gene was isolated, sequenced and its expression characterized in… Expand
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