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SHMT1 wt Allele

Known as: Serine Hydroxymethyltransferase 1 (Soluble) wt Allele, MGC15229, MGC24556 
Human SHMT1 wild-type allele is located in the vicinity of 17p11.2 and is approximately 36 kb in length. This allele, which encodes serine… 
National Institutes of Health

Related topics

Related topics

9 relations
17p11.2Amino Acid BiosynthesisCyanoamino Acid Metabolism PathwayGlycine, Serine and Threonine Metabolism Pathway

Broader (1)

SHMT1 gene

Papers overview

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Review
2016
Review
2016
Threonine aldolases: perspectives in engineering and screening the enzymes with enhanced substrate and stereo specificities
Threonine aldolases have emerged as a powerful tool for asymmetric carbon-carbon bond formation. These enzymes catalyse the… 
2014
2014
Vitamin D, folate, and potential early lifecycle environmental origin of significant adult phenotypes
Solar radiation early in pregnancy interacts with light sensitive vitamins to influence an embryo's genetic profile. This… 
Highly Cited
2009
Highly Cited
2009
SHMT1 and SHMT2 Are Functionally Redundant in Nuclear De novo Thymidylate Biosynthesis
The three enzymes that constitute the de novo thymidylate synthesis pathway in mammals, cytoplasmic serine… 
Highly Cited
2009
Highly Cited
2009
Aberrations in folate metabolic pathway and altered susceptibility to autism
Objective To investigate whether genetic polymorphisms are the underlying causes for aberrations in folate pathway that was… 
Highly Cited
2008
Highly Cited
2008
Risk of colorectal cancer associated with the C677T polymorphism in 5,10-methylenetetrahydrofolate reductase in Portuguese patients depends on the intake of methyl-donor nutrients.
BACKGROUND Polymorphisms located in genes involved in the metabolism of folate and some methyl-related nutrients are implicated… 
2008
2008
Polymorphisms in Methionine Synthase, Methionine Synthase Reductase and Serine Hydroxymethyltransferase, Folate and Alcohol Intake, and Colon Cancer Risk
Background/Aims: We examined associations among folate and alcohol intake, single nucleotide polymorphisms (SNPs) in genes… 
Highly Cited
2007
Highly Cited
2007
Association of MTHFR C677T and SHMT1 C1420T with susceptibility to ESCC and GCA in a high incident region of Northern China
ObjectiveTo assess the association between the C to T transition in the methylenetetrahydro folate reductase gene (MTHFR C677T… 
1999
1999
Ontogeny of serine hydroxymethyltransferase isoenzymes in fetal sheep liver, kidney, and placenta.
Serine is an amino acid that is not transported from the placenta to the ovine fetus. Thus, fetal plasma serine levels may be… 
Highly Cited
1998
Highly Cited
1998
Molecular cloning, characterization and alternative splicing of the human cytoplasmic serine hydroxymethyltransferase gene.
1997
1997
The Role of His-134, -147, and -150 Residues in Subunit Assembly, Cofactor Binding, and Catalysis of Sheep Liver Cytosolic Serine Hydroxymethyltransferase*
In an attempt to unravel the role of conserved histidine residues in the structure-function of sheep liver cytosolic serine… 
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