FAQ

SH3 and Multiple Ankyrin Repeat Domains Protein 3

Known as: ProSAP2, Proline-Rich Synapse-Associated Protein 2, Shank3 
SH3 and Multiple Ankyrin Repeat Domains Protein 3 (1741 aa, 186 kDa) is a cell communication protein that is encoded by the human SHANK3 gene and… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1999-2018
010203019992018

Related topics

Related topics

8 relations
Ankyrin RepeatCoiled-Coil DomainProline-Rich DomainSH3 Domain
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Related mentions per year

Related mentions per year

1940-2018
19401960198020002020
SH3 and Multiple Ankyrin Repeat Domains Protein 3
Signal Transduction
Synaptic Transmission
Coiled-Coil Domain
SHANK3 gene
Ankyrin Repeat

Papers overview

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Highly Cited
2013
Highly Cited
2013
SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties.
Mutations in SHANK3 and large duplications of the region spanning SHANK3 both cause a spectrum of neuropsychiatric disorders… (More)
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Highly Cited
2012
Highly Cited
2012
SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism
Genetic mutations of SHANK3 have been reported in patients with intellectual disability, autism spectrum disorder (ASD) and… (More)
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Highly Cited
2011
Highly Cited
2011
Shank3 mutant mice display autistic-like behaviours and striatal dysfunction
Autism spectrum disorders (ASDs) comprise a range of disorders that share a core of neurobehavioural deficits characterized by… (More)
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Highly Cited
2008
Highly Cited
2008
Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1.
Experience-dependent changes in the structure of dendritic spines may contribute to learning and memory. Encoded by three genes… (More)
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Highly Cited
2006
Highly Cited
2006
An architectural framework that may lie at the core of the postsynaptic density.
The postsynaptic density (PSD) is a complex assembly of proteins associated with the postsynaptic membrane that organizes… (More)
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2004
2004
Characterization of an ankyrin repeat-containing Shank2 isoform (Shank2E) in liver epithelial cells.
Shank proteins are a family of multidomain scaffolding proteins best known for their role in organizing the postsynaptic density… (More)
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2002
2002
ProSAP/Shank postsynaptic density proteins interact with insulin receptor tyrosine kinase substrate IRSp53.
The ProSAP/Shank family of multidomain proteins of the postsynaptic density (PSD) can either directly or indirectly interact with… (More)
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Highly Cited
2001
Highly Cited
2001
Disruption of the ProSAP2 gene in a t(12;22)(q24.1;q13.3) is associated with the 22q13.3 deletion syndrome.
The terminal 22q13.3 deletion syndrome is characterized by severe expressive-language delay, mild mental retardation, hypotonia… (More)
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Highly Cited
1999
Highly Cited
1999
Proline-rich synapse-associated protein-1/cortactin binding protein 1 (ProSAP1/CortBP1) is a PDZ-domain protein highly enriched in the postsynaptic density.
The postsynaptic density (PSD) is crucially involved in the structural and functional organization of the postsynaptic… (More)
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Highly Cited
1999
Highly Cited
1999
Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family.
We have recently isolated a novel proline-rich synapse-associated protein-1 (ProSAP1) that is highly enriched in postsynaptic… (More)
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