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SH3 and Multiple Ankyrin Repeat Domains Protein 3

Known as: ProSAP2, Proline-Rich Synapse-Associated Protein 2, Shank3 
SH3 and Multiple Ankyrin Repeat Domains Protein 3 (1741 aa, 186 kDa) is a cell communication protein that is encoded by the human SHANK3 gene and… Expand
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Several large-scale genomic studies have supported an association between cases of autism spectrum disorder and mutations in the… Expand
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Highly Cited
2013
Highly Cited
2013
Phelan–McDermid syndrome (PMDS) is a complex neurodevelopmental disorder characterized by global developmental delay, severely… Expand
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Highly Cited
2013
Highly Cited
2013
BackgroundHaploinsufficiency of SHANK3, due to either hemizygous gene deletion (termed 22q13 deletion syndrome or Phelan-McDermid… Expand
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Highly Cited
2012
Highly Cited
2012
Identification of common molecular pathways affected by genetic variation in autism is important for understanding disease… Expand
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Highly Cited
2011
Highly Cited
2011
SHANK3 is a synaptic scaffolding protein enriched in the postsynaptic density (PSD) of excitatory synapses. Small microdeletions… Expand
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Highly Cited
2008
Highly Cited
2008
AbstractmicroRNAs (miRNAs) are ~21 nt transcripts capable of regulating the expression of many mRNAs and are abundant in the… Expand
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Highly Cited
2008
Highly Cited
2008
Kalirin, a multifunctional Rho GDP/GTP exchange factor, plays a vital role in cytoskeletal organization, affecting process… Expand
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Highly Cited
2007
Highly Cited
2007
SHANK3 (also known as ProSAP2) regulates the structural organization of dendritic spines and is a binding partner of neuroligins… Expand
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Highly Cited
2007
Highly Cited
2007
Mutations in SHANK3, which encodes a synaptic scaffolding protein, have been described in subjects with an autism spectrum… Expand
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Highly Cited
2005
Highly Cited
2005
CpG islands are present in one-half of all human and mouse genes and typically overlap with promoters or exons. We developed a… Expand
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