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SH3 Domain

Known as: SH3 Domains, SRC Homology Region 3 Domain 
A region of protein sequence similarity among members of the SRC family of cytoplasmic tyrosine kinases, and other proteins. The SH3 domain is a… 
National Institutes of Health

Related topics

Related topics

50 relations
ABI2 protein, humanAMPH protein, humanASAP1 protein, humanAbelson Tyrosine-Protein Kinase 2, human

Broader (1)

src Homology Domains

Papers overview

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Highly Cited
2003
Highly Cited
2003
Aromatic and methyl NOEs highlight hydrophobic clustering in the unfolded state of an SH3 domain.
The N-terminal SH3 domain of Drosophila drk (drkN SH3 domain) exists in equilibrium between a folded (F(exch)) state and a… 
2000
2000
SETA: a novel SH3 domain-containing adapter molecule associated with malignancy in astrocytes.
Differential display polymerase chain reaction analysis was used to compare five differentiation states of the O-2A progenitor… 
Highly Cited
2000
Highly Cited
2000
Meltrin α cytoplasmic domain interacts with SH3 domains of Src and Grb2 and is phosphorylated by v-Src
Meltrin α/ADAM12 is a member of the ADAM/MDC family proteins characterized by the presence of metalloprotease and disintegrin… 
Highly Cited
2000
Highly Cited
2000
Direct interaction of SOS1 Ras exchange protein with the SH3 domain of phospholipase C-gamma1.
A recent report that microinjection of the SH3 domain of PLC-gamma1 could induce DNA synthesis raised the functional importance… 
Highly Cited
1999
Highly Cited
1999
A novel peptide–SH3 interaction
SH3 domains constitute a family of protein–protein interaction modules that bind to peptides displaying an X‐proline‐X‐X‐proline… 
Highly Cited
1998
Highly Cited
1998
Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2
Disabled-2 (Dab2), a mammalian structural homolog of Drosophila Disabled (Dab), is a mitogen-responsive phosphoprotein. It has… 
Highly Cited
1997
Highly Cited
1997
The SH3 domain of Eps8 exists as a novel intertwined dimer
SH3 domains are structurally well-characterized as monomeric modular units of protein structure that mediate protein–protein… 
Highly Cited
1997
Highly Cited
1997
Clathrin interacts specifically with amphiphysin and is displaced by dynamin 1
Highly Cited
1995
Highly Cited
1995
The SH3 Domain of Crk Binds Specifically to a Conserved Proline-rich Motif in Eps15 and Eps15R (*)
The Crk protein belongs to the family of proteins consisting of mainly Src homology 2 and 3 (SH2 and SH3) domains. These proteins… 
Highly Cited
1993
Highly Cited
1993
Microtubules and Src homology 3 domains stimulate the dynamin GTPase via its C-terminal domain.
Dynamin is a 100-kDa GTPase that plays a critical role in the initial stages of endocytosis. Dynamin binds to microtubules, which… 
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