Yanrong Ren

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Protein-DNA recognition plays a central role in the regulation of gene expression. With the rapidly increasing number of protein-DNA complex structures available at atomic resolution in recent years, a systematic, complete, and intuitive framework to clarify the intrinsic relationship between the global binding modes of these complexes is needed. In this(More)
Quantitative structure-activity relationship (QSAR), a regression modeling methodology that establishes statistical correlation between structure feature and apparent behavior for a series of congeneric molecules quantitatively, has been widely used to evaluate the activity, toxicity and property of various small-molecule compounds such as drugs, toxicants(More)
Src homology 3 (SH3) domain is a versatile protein structure module that participates in mediating various protein–protein binding events by specifically recognizing proline-rich region of diverse plasmatic proteins. Reliable and fast inference of SH3-binding partners over the human proteome are fundamentally important for our understanding of the molecular(More)
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