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SETDB1 protein, human

Known as: Histone-Lysine N-Methyltransferase SETDB1, SET Domain Bifurcated 1, Lysine N-Methyltransferase 1E 
Histone-lysine N-methyltransferase SETDB1 (1291 aa, ~143 kDa) is encoded by the human SETDB1 gene. This protein is involved in histone methylation.
National Institutes of Health

Related topics

Related topics

15 relations
DOT1L wt AlleleEnzyme GeneGene ExpressionMethylation

Broader (1)

Protein Methyltransferases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis
The serine/threonine kinase Akt plays a central role in cell proliferation, survival and metabolism, and its hyperactivation is… 
Highly Cited
2016
Highly Cited
2016
Up‐regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis
Epigenetic deregulation plays an important role in liver carcinogenesis. Using transcriptome sequencing, we examined the… 
Highly Cited
2015
Highly Cited
2015
Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells
Transposable elements comprise roughly 40% of mammalian genomes. They have an active role in genetic variation, adaptation and… 
Highly Cited
2013
Highly Cited
2013
Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis
Disruption of the histone modification patterns is one of the most common features of human tumors. However, few genetic… 
Review
2012
Review
2012
Time-lapse monitoring as a tool for clinical embryo assessment.
As elective transfer of a single embryo (eSET) becomes increasingly accepted, the need to improve implantation rates becomes… 
Highly Cited
2011
Highly Cited
2011
The SETDB1 histone methyltransferase is recurrently amplified in and accelerates melanoma
The most common mutation in human melanoma, BRAF(V600E), activates the serine/threonine kinase BRAF and causes excessive activity… 
Review
2010
Review
2010
Molecular coupling of DNA methylation and histone methylation.
The combinatorial pattern of DNA and histone modifications constitutes an epigenetic 'code' that shapes gene-expression patterns… 
Highly Cited
2010
Highly Cited
2010
Histone Demethylase LSD1 Regulates Adipogenesis*
Epigenetic mechanisms, in particular the enzymatic modification of histones, are a crucial element of cell differentiation, a… 
Highly Cited
2003
Highly Cited
2003
mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression.
Highly Cited
2003
Highly Cited
2003
Single embryo transfer and multiple pregnancy rate reduction in IVF/ICSI: a 5-year appraisal.
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