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SC 53116

Known as: SC-53116 
 
National Institutes of Health

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2 relations

Broader (2)

BenzamidesPyrroles

Papers overview

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2006
2006
Pyrrolizidine esters and amides as 5-HT4 receptor agonists and antagonists.
A series of pyrrolizidine esters, amides, and ureas was prepared and tested for 5-HT(4) and 5-HT(3) receptor binding, 5-HT(4… Expand
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2004
2004
Bridgehead-methyl analog of SC-53116 as a 5-HT4 agonist.
Pyrrolizidine benzamide (+/-)-2, the bridgehead-methyl analog of SC-53116, was prepared and evaluated for 5-HT(4) agonism… Expand
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2004
2004
Self-condensation of N-tert-butanesulfinyl aldimines: application to the rapid asymmetric synthesis of biologically important amine-containing compounds.
[reaction: see text] Highly diastereoselective intra- and intermolecular self-condensation reactions of N-tert-butanesulfinyl… Expand
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1999
1999
5-HT4 receptors in isolated human corpus cavernosum?
The novel serotonin subtype-4 (5-HT4) receptor agonist, SC53116 (SC), produced a limited relaxation of noradrenaline (NA) pre… Expand
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1997
1997
Effects of gastroprokinetic agents on gastroparesis in streptozotocin-induced diabetic rats
Abstract The influence of diabetic hyperglycemia on solid gastric emptying in rats was examined. Diabetes was produced by… Expand
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1997
1997
5-CT or DOI augments TRH analog-induced gastric acid secretion at the dorsal vagal complex.
Serotonin (5-HT) interacts with thyrotropin-releasing hormone (TRH) at the dorsal vagal complex (DVC) to augment TRH-induced… Expand
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1995
1995
Investigation of the 5-hydroxytryptamine receptor mediating the “transient” short-circuit current response in guinea-pig ileal mucosa
Abstract5-Hydroxytryptamine (5-HT) stimulated an increase in short-circuit current (Isc) in guinea-pig isolated ileal mucosa over… Expand
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1993
1993
RS 23597-190: a potent and selective 5-HT4 receptor antagonist.
1. The pharmacological properties of RS 23597-190 (3-(piperdine-1-yl)-propyl-4-amino-5-chloro-2-methoxy benzoate hydrochloride… Expand
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1993
1993
SC-53606, a potent and selective antagonist of 5-hydroxytryptamine4 receptors in isolated rat esophageal tunica muscularis mucosae.
(1-S,8-S)-N-[(hexahydro-1H-pyrrolizin-1-yl)methyl]-6-chloroimi+ ++- dazo[1,2-a]pyridine-8-carboxamide hydrochloride (SC-53606… Expand
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1992
1992
SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype.
 
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