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SC 53116

Known as: SC-53116 
National Institutes of Health

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2 relations

Broader (2)

BenzamidesPyrroles

Papers overview

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2006
2006
Pyrrolizidine esters and amides as 5-HT4 receptor agonists and antagonists.
A series of pyrrolizidine esters, amides, and ureas was prepared and tested for 5-HT(4) and 5-HT(3) receptor binding, 5-HT(4… 
2004
2004
Self-condensation of N-tert-butanesulfinyl aldimines: application to the rapid asymmetric synthesis of biologically important amine-containing compounds.
[reaction: see text] Highly diastereoselective intra- and intermolecular self-condensation reactions of N-tert-butanesulfinyl… 
2004
2004
Bridgehead-methyl analog of SC-53116 as a 5-HT4 agonist.
1999
1999
5-HT4 receptors in isolated human corpus cavernosum?
The novel serotonin subtype-4 (5-HT4) receptor agonist, SC53116 (SC), produced a limited relaxation of noradrenaline (NA) pre… 
1997
1997
Effects of gastroprokinetic agents on gastroparesis in streptozotocin-induced diabetic rats
Abstract The influence of diabetic hyperglycemia on solid gastric emptying in rats was examined. Diabetes was produced by… 
1997
1997
5-CT or DOI augments TRH analog-induced gastric acid secretion at the dorsal vagal complex.
Serotonin (5-HT) interacts with thyrotropin-releasing hormone (TRH) at the dorsal vagal complex (DVC) to augment TRH-induced… 
1995
1995
Investigation of the 5-hydroxytryptamine receptor mediating the “transient” short-circuit current response in guinea-pig ileal mucosa
Abstract5-Hydroxytryptamine (5-HT) stimulated an increase in short-circuit current (Isc) in guinea-pig isolated ileal mucosa over… 
Highly Cited
1993
Highly Cited
1993
RS 23597‐190: a potent and selective 5‐HT4 receptor antagonist
1 The pharmacological properties of RS 23597‐190 (3‐(piperdine‐1‐yl)‐propyl‐4‐amino‐5‐chloro‐2‐methoxy benzoate hydrochloride… 
1993
1993
SC-53606, a potent and selective antagonist of 5-hydroxytryptamine4 receptors in isolated rat esophageal tunica muscularis mucosae.
(1-S,8-S)-N-[(hexahydro-1H-pyrrolizin-1-yl)methyl]-6-chloroimi+ ++- dazo[1,2-a]pyridine-8-carboxamide hydrochloride (SC-53606… 
Highly Cited
1992
Highly Cited
1992
SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype.
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