R. Eglen

Publications309
h-index69
Citations15,746
Highly Influential Citations678
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Muscarinic receptor subtypes and smooth muscle function.
Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development
TLDR
Specific mAChR-regulated pathways are identified as potentially novel targets for the treatment of various important disorders including Alzheimer's disease, schizophrenia, pain, obesity and diabetes.
Structure and Function of a Novel Voltage-gated, Tetrodotoxin-resistant Sodium Channel Specific to Sensory Neurons (*)
TLDR
Functional expression in Xenopus oocytes showed that PN3 is a voltage-gated sodium channel with a depolarized activation potential, slow inactivation kinetics, and resistance to high concentrations of tetrodotoxin.
RS-102221: A Novel High Affinity and Selective, 5-HT2C Receptor Antagonist
TLDR
It is concluded that RS-102221 is the first selective, high affinity 5-HT2C receptor antagonist to be described and failed to reverse the hypolocomotion induced by the 5- HT2 receptor agonist 1-(3-chlorophenyl)piperazine (m-CPP).
Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo
TLDR
In urethane‐anaesthetized rats, the cholinergic component of volume‐induced bladder contractions was inhibited by muscarinic antagonists but had marginal effects on pinacidil‐induced, adenosine 3′:5′‐cyclic monophosphate (cyclic AMP)‐independent, relaxation, consistent with a major contribution of M2 receptors in the generation of volume-induced bladdercontractions.
Distribution of the Tetrodotoxin-Resistant Sodium Channel PN3 in Rat Sensory Neurons in Normal and Neuropathic Conditions
TLDR
The specific subcellular redistribution of PN3 after peripheral nerve injury may be an important factor in establishing peripheral nerve hyperexcitability and resultant neuropathic pain.
A comparison of the potential role of the tetrodotoxin-insensitive sodium channels, PN3/SNS and NaN/SNS2, in rat models of chronic pain.
TLDR
The biophysical properties of the tetrodotoxin-resistant current, mediated, at least in part, by the sodium channel PN3 (SNS), suggests that it may play a specialized, pathophysiological role in the sustained, repetitive firing of the peripheral neuron after injury and suggests that relief from chronic inflammatory or neuropathic pain might be achieved by selective blockade or inhibition of Pn3 expression.
Assessment of the role of α2‐adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice
1 The role of α2‐adrenoceptor (AR) subtypes in the modulation of acute nociception, motor behaviour and body temperature, has been investigated by determining the activity of the α2AR selective…
Immunocytochemical localization of P2X3 purinoceptors in sensory neurons in naive rats and following neuropathic injury
TLDR
The number of P2X3 positive small and medium diameter neurons increased in dorsal root ganglia when compared with sham-operated animals and the spinal cord immunoreactivity increased in magnitude on the side ipsilateral to the ligated nerve, consistent with up-regulation of receptors in presynaptic terminals of the primary sensory neurons.
Muscarinic receptor subtypes in neuronal and non-neuronal cholinergic function.
  • R. Eglen
  • Medicine, Biology
    Autonomic & autacoid pharmacology
  • 1 July 2006
TLDR
The availability of novel and selectivemuscarinic agonists and antagonists, as well as in vivo gene disruption techniques, has clarified the roles of muscarinic receptors in mediating both functions of acetylcholine.
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