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Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter.
There are three known high-affinity targets for cocaine: the dopamine transporter (DAT), the serotonin transporter (SERT), and the norepinephrine transporter (NET). Decades of studies support theExpand
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Role of spinal cord glutamate transporter during normal sensory transmission and pathological pain states
Glutamate is a neurotransmitter critical for spinal excitatory synaptic transmission and for generation and maintenance of spinal states of pain hypersensitivity via activation of glutamateExpand
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Spinal glutamate uptake is critical for maintaining normal sensory transmission in rat spinal cord
Glutamate is a major excitatory neurotransmitter in primary afferent terminals and is critical for normal spinal excitatory synaptic transmission. However, little is known about the regulation ofExpand
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Antioxidants attenuate multiple phases of formalin-induced nociceptive response in mice
An emerging theme in the study of the pathophysiology of chronic and persistent pain is the role of pro-oxidant substances. Reactive oxygen species (ROS) have been implicated in contributing toExpand
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Abdominal Surgery‐ and Trephination‐Induced Delay in Gastric Emptying is Prevented by Intracisternal Injection of CRF Antagonist in the Rat
The role of endogenous corticotropin‐releasing factor (CRF) in mediating surgery‐induced delay in gastric emptying of a noncaloric solution was studied in rats using intracisternal injection of a CRFExpand
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Glutamate uptake is attenuated in spinal deep dorsal and ventral horn in the rat spinal nerve ligation model
Alteration of glutamatergic (GLU) neurotransmission within the spinal cord contributes to hyperalgesic and allodynic responses following nerve injury. In particular, changes in expression andExpand
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TRH analogue microinjected into specific medullary nuclei stimulates gastric serotonin secretion in rats.
Brain nuclei involved in vagal release of gastric serotonin (5-HT) were investigated in urethan-anesthetized rats acutely implanted with gastric cannula. Gastric secretions were collected every 10-15Expand
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Quantitative Assessment and Characterization of Visceral Hyperalgesia Evoked by Esophageal Balloon Distention and Acid Perfusion in Patients With Functional Heartburn, Nonerosive Reflux Disease, and
Background and ObjectivesThe role of esophageal hypersensitivity in functional heartburn (FH) with negative pH test, negative symptom index, and the proton pump inhibitor (PPI) failure has not beenExpand
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Endogenous Serotonin Produces an Inhibitory Tone on Vagally Stimulated Gastric Function a
The effect of depletion of serotonin stores on vagally stimulated gastric acid secretion and motility was studied in rats. Pretreatment of rats with parachlorophenylalanine (p-CPA) produced a 57%Expand
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Intracisternal injection of peptide YY inhibits gastric emptying in rats
Peptide YY (PYY) has been shown to effectively regulate gastrointestinal function when administered intravenously. In the present study, the effect of intracisternal (i.c.) injection of rat PYY onExpand
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