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An evidence-based definition of lifelong premature ejaculation: report of the International Society for Sexual Medicine (ISSM) ad hoc committee for the definition of premature ejaculation.
TLDR
The ISSM definition of lifelong PE represents the first evidence-based definition of PE, and will hopefully lead to the development of new tools and Patient Reported Outcome measures for diagnosing and assessing the efficacy of treatment interventions and encourage ongoing research into the true prevalence of this disorder. Expand
An Update of the International Society of Sexual Medicine's Guidelines for the Diagnosis and Treatment of Premature Ejaculation (PE)
TLDR
An update of the International Society of Sexual Medicine's guidelines for the diagnosis and treatment of premature ejaculation (PE) and best practices treatment recommendations are presented to guide clinicians, both familiar and unfamiliar with PE, in facilitating treatment of their patients. Expand
An update of the International Society of Sexual Medicine's guidelines for the diagnosis and treatment of premature ejaculation (PE).
TLDR
A new unified definition of PE is offered and best practices treatment recommendations are presented to guide clinicians, both familiar and unfamiliar with PE, in facilitating treatment of their patients. Expand
Papaya (Carica papaya) consumption is unsafe in pregnancy: fact or fable? Scientific evaluation of a common belief in some parts of Asia using a rat model
TLDR
The results of the present study suggest that normal consumption of ripe papaya during pregnancy may not pose any significant danger, however, the unripe or semi-ripe papaya (which contains high concentration of the latex that produces marked uterine contractions) could be unsafe in pregnancy. Expand
Hydrogen sulphide: a novel endogenous gasotransmitter facilitates erectile function.
TLDR
These pioneering studies provide evidence for the endogenous formation of H2S and its proerectile relaxant effect on the cavernosum, with the possibility of involvement of the cyclic adenosine monophosphate pathway. Expand
An evidence‐based definition of lifelong premature ejaculation: report of the International Society for Sexual Medicine Ad Hoc Committee for the Definition of Premature Ejaculation
TLDR
To develop a contemporary, evidence‐based definition of premature ejaculation, a large number of experts believe that men and women experiencing early ejaculation should be considered to be sexually active before the age of 25. Expand
Possible role for the novel gasotransmitter hydrogen sulphide in erectile dysfunction--a pilot study.
TLDR
A possible role for endogenous hydrogen sulphide in erectile physiopharmacology through facilitation of nerve-mediated penile tumescence is suggested and the inhibitory effect of propargylglycine on the proerectile pathway is confirmed. Expand
Hydrogen sulfide promotes nitric oxide production in corpus cavernosum by enhancing expression of endothelial nitric oxide synthase
TLDR
It is ascertain that H2S could exert its proerectile effects by augmenting NO pathway and would be particularly useful in improving the clinical outcome of ED patients, whose erectile impairment is due to an inherent attenuation of the endothelial NO formation in the cavernosum. Expand
Mechanisms of direct relaxant effect of sildenafil, tadalafil and vardenafil on corpus cavernosum.
  • L. Lau, P. Adaikan
  • Chemistry, Medicine
  • European journal of pharmacology
  • 17 July 2006
TLDR
The results indicate that vardenafil and sildenafil possess direct muscle relaxant potential possibly via inhibiting Ca(2+) influx through both receptor-operated and voltage-dependent Ca( 2+) channels whereas tadalafil appears capable of inhibiting receptor- operated transmembrane Ca(1+) entry only. Expand
Proerectile pharmacological effects of Tribulus terrestris extract on the rabbit corpus cavernosum.
TLDR
The relaxant responses to acetylcholine, nitroglycerin and EFS and the lack of such effect on the contractile response to noradrenaline and histamine indicate that PTN has a proerectile activity, which may account for its claims as an aphrodisiac. Expand
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