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SB 277011

Known as: SB 277011-A, SB-277011, SB-277011-A 
 
National Institutes of Health

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2 relations

Broader (2)

NitrilesTetrahydroisoquinolines

Papers overview

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Highly Cited
2010
Highly Cited
2010
The selective dopamine D3 receptor antagonist SB 277011-A, but not the partial agonist BP 897, blocks cue-induced reinstatement of nicotine-seeking.
The dopamine D3 receptor (DRD3) has been suggested to be involved in the mechanisms underlying stimulus-controlled drug-seeking… Expand
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Highly Cited
2009
Highly Cited
2009
In vivo quantification of regional dopamine-D3 receptor binding potential of (+)-PHNO: Studies in non-human primates and transgenic mice.
Examination of dopamine-D3 (D3) receptors with positron emission tomography (PET) have been hampered in the past by the lack of a… Expand
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Highly Cited
2005
Highly Cited
2005
The selective dopamine D3 receptor antagonist SB-277011-A attenuates ethanol consumption in ethanol preferring (P) and non-preferring (NP) rats
The mesolimbic dopamine (DA) system plays an important role in mediating addiction to alcohol and other drugs of abuse. Recent… Expand
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2004
2004
Selective dopamine D(3) receptor antagonist SB-277011-A potentiates phMRI response to acute amphetamine challenge in the rat brain.
Dopamine (DA) receptors are a major target for drugs employed in the treatment of neuropsychiatric disorders such as… Expand
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Highly Cited
2003
Highly Cited
2003
Attenuation of Cue-Controlled Cocaine-Seeking by a Selective D3 Dopamine Receptor Antagonist SB-277011-A
Conditioned stimuli (CS) previously paired with drugs of abuse can elicit cravings in humans, relapse to drug use, and can also… Expand
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Highly Cited
2002
Highly Cited
2002
Dopamine D3 Receptor Antagonism Inhibits Cocaine-Seeking and Cocaine-Enhanced Brain Reward in Rats
The dopamine D3 receptor is preferentially localized to the mesocorticolimbic dopaminergic system and has been hypothesized to… Expand
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2001
2001
Pharmacokinetics of the novel, high-affinity and selective dopamine D3 receptor antagonist SB-277011 in rat, dog and monkey: in vitro/in vivo correlation and the role of aldehyde oxidase
1. In vitro studies with the selective dopamine D3 receptor antagonist SB-277011 were conducted in liver microsomes and… Expand
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Review
2001
Review
2001
SB-277011 GlaxoSmithKline.
It is presumed that GlaxoSmithKline has taken over from SmithKline Beecham in investigating the highly selective dopamine D3… Expand
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Highly Cited
2000
Highly Cited
2000
Pharmacological actions of a novel, high-affinity, and selective human dopamine D(3) receptor antagonist, SB-277011-A.
SB-277011-A (trans-N-[4-[2-(6-cyano-1,2,3, 4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolininecarboxamide), is a brain… Expand
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Highly Cited
2000
Highly Cited
2000
Design and synthesis of trans-N-[4-[2-(6-cyano-1,2,3, 4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): A potent and selective dopamine D(3) receptor antagonist with…
A selective dopamine D(3) receptor antagonist offers the potential for an effective antipsychotic therapy, free of the serious… Expand
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