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Limbic Seizures Induce P-Glycoprotein in Rodent Brain: Functional Implications for Pharmacoresistance
TLDR
Changes in P-gp mRNA levels occur in limbic areas after both acute and chronic epileptic activity, suggesting that seizure-induced mdr mRNA expression contributes to MDR in epilepsy.
Kinetics of MK-801 and its effect on quinolinic acid-induced seizures and neurotoxicity in rats.
TLDR
The anticonvulsant effect of MK-801 was evaluated against limbic seizures induced by intrahippocampal injection of 120 nmol of quinolinic acid, an agonist of the N-methyl-D-aspartate-type receptors, in freely moving rats and significantly lowered the number of seizures and the total time spent in seizures.
Influence of dose and route of administration on the kinetics of fluoxetine and its metabolite norfluoxetine in the rat
TLDR
Brain concentrations reflected the plasma kinetics of FL and NFL and the metabolite-to-parent drug ratio varied with dose and time of administration and was modified at the highest dose tested.
Genotype-Dependent Activity of Tryptophan Hydroxylase-2 Determines the Response to Citalopram in a Mouse Model of Depression
TLDR
The results suggest that the failure of citalopram to reduce immobility time in DBA/2J and BALB/c mice is attributable to genotype-dependent impairment of 5-HT synthesis, a mechanism underlying the response to selective serotonin reuptake inhibitors.
The SIRT1 activator resveratrol protects SK‐N‐BE cells from oxidative stress and against toxicity caused by α‐synuclein or amyloid‐β (1‐42) peptide
TLDR
SIRT1 activation by RES can prevent in the neuroblastoma model the deleterious effects triggered by oxidative stress or α‐syn(A30P) aggregation, while RES displayed a SIRT1‐independent protective action against Aβ42.
Role of hyperforin in the antidepressant-like activity of Hypericum perforatum extracts
TLDR
The view that hyperforin plays a key role in the antidepressant-like activity of Hypericum p.
Glutamate AMPA receptors change in motor neurons of SOD1G93A transgenic mice and their inhibition by a noncompetitive antagonist ameliorates the progression of amytrophic lateral sclerosis‐like
TLDR
Treatment with a new noncompetitive AMPA antagonist, ZK 187638, partially protected motor neurons, improved motor function, and prolonged the survival of SOD1G93A mice.
Prevention of Inappropriate Prescribing in Hospitalized Older Patients Using a Computerized Prescription Support System (INTERcheck®)
TLDR
The use of INTERCheck® was associated with a significant reduction in PIMs and new-onset potentially severe DDIs, and CPSSs combining different prescribing quality measures should be considered as an important strategy for optimizing medication prescription for elderly patients.
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