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Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia.
- S. Kapur
- Psychology, MedicineThe American journal of psychiatry
A heuristic framework for linking the psychological and biological in psychosis is provided and it is proposed that a dysregulated, hyperdopaminergic state, at a "brain" level of description and analysis, leads to an aberrant assignment of salience to the elements of one's experience, at an "mind" level.
The dopamine hypothesis of schizophrenia: version III--the final common pathway.
The dopamine hypothesis of schizophrenia-version III is synthesized into a comprehensive framework that links risk factors, including pregnancy and obstetric complications, stress and trauma, drug use, and genes, to increased presynaptic striatal dopaminergic function.
Grand challenges in global mental health
A consortium of researchers, advocates and clinicians announces here research priorities for improving the lives of people with mental illness around the world, and calls for urgent action and…
Hemispheric encoding/retrieval asymmetry in episodic memory: positron emission tomography findings.
- E. Tulving, S. Kapur, F. Craik, M. Moscovitch, S. Houle
- Psychology, BiologyProceedings of the National Academy of Sciences…
- 15 March 1994
A hemispheric encoding/retrieval asymmetry model of prefrontal involvement in encoding and retrieval of episodic memory is proposed, which suggests that left and right prefrontal lobes are part of an extensive neuronal network that subserves episodic remembering, but the two prefrontal hemispheres play different roles.
Antipsychotic Dosing in Preclinical Models Is Often Unrepresentative of the Clinical Condition: A Suggested Solution Based on in Vivo Occupancy
- S. Kapur, S. C. VanderSpek, B. A. Brownlee, J. Nobrega
- Medicine, PsychologyJournal of Pharmacology and Experimental…
- 1 May 2003
The study provides a rationale as well as clinically comparable dosing regimens for animal studies and raises questions about the inferences drawn from previous studies that have used doses unrepresentative of the clinical situation.
In Search of the Self: A Positron Emission Tomography Study
Previous work using positron emission tomography (PET) has shown that memory encoding processes are associated with preferential activation of left frontal regions of the brain, whereas retrieval…
Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics?: A new hypothesis.
It is predicted that the atypical antipsychotic effect can be produced by appropriate modulation of the D(2) receptor alone; the blockade of other receptors is neither necessary nor sufficient.
Age-Related Differences in Neural Activity during Memory Encoding and Retrieval: A Positron Emission Tomography Study
The results indicate that advanced age is associated with neural changes in the brain systems underlying encoding, recognition, and recall that take two forms: age- related decreases in local regional activity, which may signal less efficient processing by the old, and age-related increases in activity,Which may signal functional compensation.
The Maudsley Prescribing Guidelines in Psychiatry
Books now will appear in printed and soft file collection and one of them is this book the maudsley prescribing guidelines in psychiatry, which will help people to discover the best thing to discover.
Opposite Effects of Δ-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology
Functional magnetic resonance imaging in healthy volunteers found that Δ-9-THC and CBD can have opposite effects on regional brain function, which may underlie their different symptomatic and behavioral effects, and CBD's ability to block the psychotogenic effects of Δ- 9- THC.