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SB 204070A

Known as: 1,4-Benzodioxin-5-carboxylic acid, 8-amino-7-chloro-2,3-dihydro-, (1-butyl-4-piperidinyl)methyl ester, monohydrochloride, SB-204070, SB 204070 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (3)

DioxanesPiperidinesSerotonin Antagonists

Papers overview

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2008
2008
Synergy between 5‐HT4 receptor activation and acetylcholinesterase inhibition in human colon and rat forestomach
Abstract  5‐Hydroxytryptamine (5‐HT4) receptor agonists increase gastrointestinal (GI) motility by enhancing enteric… 
Highly Cited
2006
Highly Cited
2006
5‐HT4 receptor agonists enhance both cholinergic and nitrergic activities in human isolated colon circular muscle
Abstract  Previous studies have demonstrated mixed inhibitory and facilitatory effects of 5‐hydroxytryptamine‐4 (5‐HT4) receptor… 
Highly Cited
2004
Highly Cited
2004
5-HT induces duodenal mucosal bicarbonate secretion via cAMP- and Ca2+-dependent signaling pathways and 5-HT4 receptors in mice.
In previous studies, we have found that 5-hydroxytryptamine (5-HT) is a potent stimulant of duodenal mucosal bicarbonate… 
2003
2003
5‐HT7 receptors mediate the inhibitory effect of 5‐HT on peristalsis in the isolated guinea‐pig ileum
The study was undertaken to investigate the 5‐HT receptor mediating the inhibitory effect of 5‐HT on peristalsis in the guinea… 
2003
2003
Pharmacological characterization of an adenylyl cyclase-coupled 5-HT receptor in aplysia: comparison with mammalian 5-HT receptors.
We attempted to identify compounds that are effective in blocking the serotonin (5-hydroxytryptamine, 5-HT) receptor(s) that… 
Highly Cited
2002
Highly Cited
2002
5-HT7 receptors modulate synchronized network activity in rat hippocampus
2001
2001
Changes in serotonin levels and 5-HT receptor activity in duodenum of streptozotocin-diabetic rats.
Few previous studies have discussed the changes in serotonin receptor activity in the small intestine of diabetic animals… 
Highly Cited
1996
Highly Cited
1996
Participation of 5-HT3, 5-HT4, and nicotinic receptors in the peristaltic reflex of guinea pig distal colon.
The roles of 5-hydroxytryptamine3 (5-HT3), 5-HT4, and nicotinic receptors in the peristaltic reflex were investigated in isolated… 
1995
1995
Antagonism by SB 204070 of 5‐HT‐evoked Contractions in the Dog Stomach: an In‐vivo Model of 5‐HT4 Receptor Function
The ability of 5‐hydroxytryptamine (5‐HT) to evoke contractile activity in the gastric Heidenhain pouch was measured in conscious… 
Highly Cited
1994
Highly Cited
1994
The effects of SB 204070, a highly potent and selective 5‐HT4 receptor antagonist, on guinea‐pig distal colon
1 The pharmacology of a novel 5‐HT4 receptor antagonist, SB 204070 has been evaluated in the guinea‐pig isolated distal colon… 
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