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Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist
TLDR
SB-366791 is a new TRPV1 antagonist with high potency and an improved selectivity profile with respect to other commonly used TRPv1 antagonists, and may prove to be a useful tool to further study the biology of TRpV1. Expand
Epileptogenesis and Enhanced Prepulse Inhibition in GABAB1-Deficient Mice
TLDR
The data suggest that GABA(B) receptor antagonists may be of benefit in the treatment of psychiatric and neurological disorders in which attentional processing is impaired, and the development of a GABA( B1) subunit knockout mouse using gene targeting techniques is developed. Expand
Age‐Dependent Synapse Withdrawal at Axotomised Neuromuscular Junctions in Wlds Mutant and Ube4b/Nmnat Transgenic Mice
TLDR
Wld expression unmasks age‐dependent, compartmentally organised programmes of synapse withdrawal and degeneration in WldS mutant mice and identifies two distinct neuromuscular synaptic responses to axotomy. Expand
Evaluation of the mGlu8 receptor as a putative therapeutic target in schizophrenia
TLDR
Analysis of the biological effects of the selective mGluR8 agonist (S-3,4-dicarboxyphenylglycine) in schizophrenia-related animal models and mouse behavioral phenotyping suggest that mGLUR8 may not be a therapeutic target for schizophrenia. Expand
Pharmacological characterisation of the orexin receptor subtype mediating postsynaptic excitation in the rat dorsal raphe nucleus
TLDR
Data suggest a differential role for OX1 and OX2 receptors in stimulating distinct populations of monoaminergic neurones in the rat CNS with Ox2 receptors exhibiting a more pronounced functional significance in serotonergic DRN neurones and Ox1 in noradrenergic neurONES. Expand
SB-334867-A antagonises orexin mediated excitation in the locus coeruleus
TLDR
The data demonstrate that SB-334867-A is a useful tool compound with which to study the physiology of OX1 receptors and finds no evidence for tonic activation of Ox1 receptors in LC noradrenergic neurones despite electron microscopic evidence that orexin terminals directly contact these neurones. Expand
SB-699551-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4′-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), a novel 5-ht5A receptor-selective antagonist, enhances
TLDR
Evidence is provided for an autoreceptor role for the 5-ht5A receptor in guinea pig brain and a failure to affect both electrically-evoked 5-HT release and 5-CT-induced inhibition of evoked release measured using fast cyclic voltammetry in vitro. Expand
5-HT7 receptors modulate synchronized network activity in rat hippocampus
TLDR
There was a shortening of the burst event waveform and a reduction in the after-hyperpolarization following each bursting event both of which were inhibited by SB-269970, which appeared to result predominantly from a direct 5-HT(7) receptor-mediated inhibition of a Ca2+ activated K+ channel. Expand
Enhanced recovery after surgery for primary hip and knee arthroplasty: a review of the evidence.
TLDR
This narrative review presents a model ERAS pathway that can be applied to perioperative care of patients undergoing hip or knee arthroplasty, and identifies interventions lacking high-quality evidence. Expand
Opioid-free anesthesia within an enhanced recovery after surgery pathway for minimally invasive lumbar spine surgery: a retrospective matched cohort study.
TLDR
OFA within an ERAS pathway for lumbar spinal decompression represents an opportunity to minimize perioperative opioid exposure without adversely affecting pain control or recovery and highlights the postoperative phase of care as a time when resources should be focused to increase ERAS adherence. Expand
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