The serotonin signaling system: from basic understanding to drug development for functional GI disorders.
- M. Gershon, J. Tack
- Biology, MedicineGastroenterology
- 2007
The initial success encountered with serotonergic agents holds promise for newer and more potent insights and therapies of brain-gut disorders.
Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome.
- M. Coates, C. R. Mahoney, P. Moses
- Medicine, BiologyGastroenterology
- 1 June 2004
Findings support the assertion that disordered gastrointestinal function in IBS involves changes intrinsic to the bowel and suggest that shared defects in 5-HT signaling may underlie the altered motility, secretion, and sensation.
Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With ASDs: A Consensus Report
- T. Buie, D. Campbell, H. Winter
- MedicinePediatrics
- 1 January 2010
The consensus expert opinion of the panel was that individuals with ASDs deserve the same thoroughness and standard of care in the diagnostic workup and treatment of gastrointestinal concerns as should occur for patients without ASDs.
Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential
- D. Worthley, M. Churchill, T. Wang
- Biology, MedicineCell
- 15 January 2015
Enteric nervous system
- M. Gershon, P. Wade
- MedicineAnnual Review of Neuroscience
- 1 March 1993
It is established that some primary afferent neurons (which are cholinergic and costore calbindin and substance P) are submucosal, and one type of myenteric neuron, 2/AH, has also been postulated to be aPrimary afferent, although some believe it is an interneuron.
Denervation suppresses gastric tumorigenesis
- Chun‐Mei Zhao, Y. Hayakawa, Duan Chen
- Medicine, BiologyScience Translational Medicine
- 1 August 2014
It is suggested that vagal innervation contributes to gastric tumorigenesis via M3 receptor–mediated Wnt signaling in the stem cells, and that denervation might represent a feasible strategy for the control of gastric cancer.
5-HT4 Receptor-Mediated Neuroprotection and Neurogenesis in the Enteric Nervous System of Adult Mice
- Min-tsai Liu, Y. Kuan, Jing-wen Wang, R. Hen, M. Gershon
- Biology, MedicineJournal of Neuroscience
- 5 August 2009
This is the first demonstration of adult enteric neurogenesis and the results suggest that 5-HT4 receptors are required postnatally for ENS growth and maintenance.
Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche.
- Y. Hayakawa, H. Ariyama, T. Wang
- Biology, MedicineCancer Cell
- 1 November 2015
Review article: serotonin receptors and transporters — roles in normal and abnormal gastrointestinal motility
- M. Gershon
- Biology, MedicineAlimentary Pharmacology and Therapeutics
- 1 November 2004
The gut is the only organ that can display reflexes and integrative neuronal activity even when isolated from the central nervous system, and the observation that molecular defects occur in the human gut in irritable bowel syndrome strengthens the hand of those seeking to legitimize the disease.
Maternal serotonin is crucial for murine embryonic development
- F. Côté, C. Fligny, G. Vodjdani
- Biology, PsychologyProceedings of the National Academy of Sciences
- 2 January 2007
Observations provide the first clear evidence that maternal serotonin is involved in the control of morphogenesis during developmental stages that precede the appearance of serotonergic neurons and (ii) serotonin is critical for normal murine development.
...
...