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SB 242084, a Selective and Brain Penetrant 5-HT2C Receptor Antagonist
TLDR
The results suggest that SB 242084 is the first reported selective potent and brain penetrant 5- HT2C receptor antagonist and has anxiolytic-like activity, but does not possess either proconvulsant or hyperphagic properties which are characteristic of mutant mice lacking the 5-HT2C receptors. Expand
In vitro and in vivo profile of SB 206553, a potent 5‐HT2C/5‐HT2B receptor antagonist with anxiolytic‐like properties
TLDR
The results suggest that SB 206553 is a potent mixed 5‐HT2C/5-HT2B receptor antagonist with selectivity over the 5‐ HT2A and all other sites studied and possesses anxiolytic‐like properties. Expand
5-HT2 receptor subtypes: a family re-united?
TLDR
The pharmacology of both officially recognized and atypical 5- HT2 receptor subtypes is examined and a number of novel selective agents are highlighted, some of which may prove useful for 5-HT2 receptor classification and clarify the mechanistic basis for current and future therapeutic strategies which target this receptor family. Expand
Pharmacological characterisation of the agonist radioligand binding site of 5-HT2A, 5-HT2B and 5-HT2C receptors
TLDR
The results indicate the importance of defining the selectivity of pharmacological tools, which may have been over-estimated in the past, and highlights the need to find more selective agonists to investigate 5-HT2 receptor pharmacology. Expand
Preferential effects of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body weight gain of obese (fa/fa) compared to lean Zucker rats
TLDR
It is indicated that chronic oral treatment with SR 141716 significantly reduces the food intake and body weight gain of obese and lean Zucker rats, an effect that is greater in obese animals and reversible upon drug withdrawal. Expand
Evidence that mCPP may have behavioural effects mediated by central 5‐HT1C receptors
TLDR
As mianserin, cyproheptadine and mesulergine in the absence of mCPP did not increase locomotion but increased the number of feeding scores, the activation of 5‐HT1C‐receptors may be of physiological importance in the control of appetite. Expand
The muscarinic receptor agonist xanomeline has an antipsychotic-like profile in the rat.
TLDR
Xanomeline attenuated amphetamine-induced hyperactivity at doses that had no effect on spontaneous activity, possibly indicating a separation between attenuation of limbic hyperdopaminergic function and the induction of hypolocomotion. Expand
Modulation of 5-HT2A receptor-mediated head-twitch behaviour in the rat by 5-HT2C receptor agonists
The pharmacology of several commonly described 5-hydroxytryptamine (5-HT)2C receptor agonists was investigated in vivo and in vitro at rat 5-HT2A, 5-HT2B, and 5-HT2C receptors. The 5-HT2C receptorExpand
Modulation of 5-HT(2A) receptor-mediated head-twitch behaviour in the rat by 5-HT(2C) receptor agonists.
TLDR
The in vivo and in vitro data suggest that for some ligands, previous reports have overestimated their in vivo selectivity for the 5-HT(2C) receptor. Expand
Female rats are more vulnerable than males in an animal model of depression: the possible role of serotonin
TLDR
Female rats were less affected by a single restraint but failed to adapt to the repeated stress procedure and did not exhibit enhanced sensitivity to 5-methoxy-N,N-dimethyltryptamine. Expand
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