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S 1360

Known as: S-1360, S1360 cpd 
National Institutes of Health

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Broader (2)

FuransTriazoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
HIV-1 IN strand transfer chelating inhibitors: a focus on metal binding.
Most active and selective strand transfer HIV-1 integrase (IN) inhibitors contain chelating functional groups that are crucial… 
2009
2009
Potent inhibitors of HIV-1 integrase display a two-step, slow-binding inhibition mechanism which is absent in a drug-resistant T66I/M154I mutant.
Two-metal binding HIV-1 integrase inhibitors (INIs) are potent inhibitors of HIV-1 in vitro and in patients. We report here for… 
2005
2005
Beta-diketo acid pharmacophore hypothesis. 1. Discovery of a novel class of HIV-1 integrase inhibitors.
HIV-1 Integrase (IN) is an essential enzyme for viral replication. The discovery of beta-diketo acids was crucial in the… 
Highly Cited
2004
Highly Cited
2004
Active site binding modes of the beta-diketoacids: a multi-active site approach in HIV-1 integrase inhibitor design.
Highly Cited
2004
Highly Cited
2004
Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360
Objectives: Study of HIV-1 resistance development to the diketo analogue S-1360, the first HIV-1 integrase strand transfer… 
Highly Cited
2004
Highly Cited
2004
Enzymology of a carbonyl reduction clearance pathway for the HIV integrase inhibitor, S-1360: role of human liver cytosolic aldo-keto reductases.
2004
2004
ANTI-HIV CHEMOTHERAPY: CURRENT STATE OF THE ART
In recent years, significant progress has been made towards the chemotherapy (and ?prophylaxis) of HIV infections. This progress… 
Review
2003
Review
2003
S-1360 Shionogi-GlaxoSmithKline.
Shionogi and GlaxoSmithKline, as the joint venture company Shionogi-GlaxoSmithKline Pharmaceuticals, is developing S-1360, an HIV… 
Highly Cited
2003
Highly Cited
2003
Development of Resistance against Diketo Derivatives of Human Immunodeficiency Virus Type 1 by Progressive Accumulation of Integrase Mutations
ABSTRACT The diketo acid L-708,906 has been reported to be a selective inhibitor of the strand transfer step of the human… 
Review
2003
Review
2003
Small-molecule HIV-1 integrase inhibitors: the 2001-2002 update.
Integration of viral DNA into host cell chromosomal DNA to form a provirus is an essential step in the viral life cycle. This… 
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