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CXCR4-activated astrocyte glutamate release via TNFα: amplification by microglia triggers neurotoxicity
Astrocytes actively participate in synaptic integration by releasing transmitter (glutamate) via a calcium-regulated, exocytosis-like process. Here we show that this process follows activation of theExpand
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Inhibition of T-tropic HIV Strains by Selective Antagonization of the Chemokine Receptor CXCR4
Bicyclams are a novel class of antiviral compounds that are highly potent and selective inhibitors of the replication of HIV-1 and HIV-2. Surprisingly, however, when the prototype compound AMD3100Expand
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The bicyclam AMD3100 story
  • E. Clercq
  • Medicine
  • Nature Reviews Drug Discovery
  • 1 July 2003
The discovery and development of the bicyclam AMD3100 — a chemokine receptor antagonist — has highlighted the therapeutic potential of such compounds in HIV infection, inflammatory diseases, cancerExpand
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Frontiers in Microbiology
  • E. Clercq
  • Biology
  • New Perspectives in Clinical Microbiology
  • 1987
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Antiviral drugs in current clinical use.
The current armamentarium for the chemotherapy of viral infections consists of 37 licensed antiviral drugs. For the treatment of human immunodeficiency virus (HIV) infections, 19 compounds have beenExpand
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Acyclic nucleoside phosphonates: a key class of antiviral drugs
Almost 20 years after the broad antiviral activity spectrum of the first acyclic nucleoside phosphonates was described, several of these compounds have become important therapies for DNA virus andExpand
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Identification of a Subset of Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus Strains Able To Exploit an Alternative Coreceptor on Untransformed Human Brain and
ABSTRACT The chemokine receptors CCR5 and CXCR4 are the major coreceptors for human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV). At least 12 other chemokine receptors orExpand
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Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives
IN the search for compounds active against human immunodeficiency virus (HIV), we have found that members of a novel series of tetrahydro-imidazo[4,5,1-jk][l,4]-benzodiazepin-2(1H)-one and -thioneExpand
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A novel selective broad-spectrum anti-DNA virus agent
A new compound has been found, (S)-9-(3-hydroxy-2-phosphonyl-methoxypropyl)adenine ((S)-HPMPA), that has potent and selective activity against a broad spectrum of DNA viruses, including herpesExpand
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Treatment of herpes simplex virus infections
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