Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360

@article{Fikkert2004MultipleMI,
  title={Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360},
  author={V. Fikkert and A. Hombrouck and B. Van Remoortel and M. de Maeyer and C. Pannecouque and E. de Clercq and Z. Debyser and M. Witvrouw},
  journal={AIDS},
  year={2004},
  volume={18},
  pages={2019-2028}
}
  • V. Fikkert, A. Hombrouck, +5 authors M. Witvrouw
  • Published 2004
  • Biology, Medicine
  • AIDS
  • Objectives: Study of HIV-1 resistance development to the diketo analogue S-1360, the first HIV-1 integrase strand transfer inhibitor that has entered clinical development. Design: HIV-1(IIIB) was passaged in cell culture in the presence of increasing concentrations of S-1360 (IIIB/S-1360res). Methods: The IIIB/S-1360res strains selected for 30, 50 and 70 passages in the presence of S-1360 were evaluated genotypically by sequencing analysis and phenotypically using the MT-4/MTT assay. Results… CONTINUE READING
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