Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360
Integrase-chimeric virus technology confirmed that the integrase mutations are indeed fully responsible for the resistance phenotype of IIIB/S-1360res, the first HIV-1 integrase strand transfer inhibitor that has entered clinical development.
Viral aetiology of influenza-like illness in Belgium during the influenza A(H1N1)2009 pandemic
- A. Hombrouck, M. Sabbe, I. Thomas
- Medicine, BiologyEuropean Journal of Clinical Microbiology and…
- 1 June 2012
Influenza A(H1N1)2009 was the most detected virus in ILI patients during the 2009–2010 winter, suggesting a good correlation between ILI case definition and influenza diagnosis.
Overexpression of the Lens Epithelium-Derived Growth Factor/p75 Integrase Binding Domain Inhibits Human Immunodeficiency Virus Replication
Data support LEDGF/p75 as an important cofactor for HIV replication and provide proof of concept for the LEDGF /p75-integrase interaction as a novel target for treating HIV-1 infection.
Virus Evolution Reveals an Exclusive Role for LEDGF/p75 in Chromosomal Tethering of HIV
The results underline the importance of the LEDGF/p75 HIV-1 interplay as target for innovative antiviral therapy and stimulate research on strategies to direct gene therapy vectors into safe landing sites.
Circulating Follicular Regulatory T Cells Are Defective in Multiple Sclerosis
It is concluded that circulating TFR are a circulating memory population derived from lymphoid resident TFR, making them a valid alternative to investigate alterations in germinal center responses in the context of autoimmune diseases, and TFR impairment is prominent in MS.
Four-tiered pi interaction at the dimeric interface of HIV-1 integrase critical for DNA integration and viral infectivity.
Influenza A/H1N1 vaccine in patients treated by kidney transplant or dialysis: a cohort study.
- N. Broeders, A. Hombrouck, D. Abramowicz
- Medicine, BiologyAmerican Society of Nephrology. Clinical Journal
- 1 November 2011
The influenza A/H1N1-adjuvanted vaccine is of limited efficacy but is safe in renal disease populations and the humoral response is lower in transplanted versus hemodialyzed patients.
Mutations in Human Immunodeficiency Virus Type 1 Integrase Confer Resistance to the Naphthyridine L-870,810 and Cross-Resistance to the Clinical Trial Drug GS-9137
The accumulation of L74M, E92Q, and S230N mutations in the integrase causes resistance to the naphthyridine L-870,810 and cross-resistance to GS-9137, which may have implications for cross-Resistance of different integrase inhibitors in the clinic.
Association of polymorphisms in the LEDGF/p75 gene (PSIP1) with susceptibility to HIV-1 infection and disease progression
Genetic variants of PSIP1 may affect HIV-1 outcomes and further studies are needed to confirm the effect of genetic variation of PSip1 on HIV- 1 pathogenesis in different cohorts.