Susceptibility of HIV-2, Siv and Shiv to Various Anti-HIV-1 Compounds: Implications for Treatment and Postexposure Prophylaxis
- M. Witvrouw, C. Pannecouque, W. Switzer, T. Folks, E. Clercq, W. Heneine
- Biology, MedicineAntiviral Therapy
- 1 January 2004
Findings support the use of NRTIs, tenofovir, but not NN RTIs, for treating HIV-2-infected persons or for prophylaxis against HIV- 2 and SIV, and show co-receptor antagonists such as AMD3100 show promising anti-HIV-2 therapeutic modalities.
Sulfated polysaccharides extracted from sea algae as potential antiviral drugs.
- M. Witvrouw, E. De Clercq
- BiologyGeneral Pharmacology
- 1 October 1997
Integrase Mutants Defective for Interaction with LEDGF/p75 Are Impaired in Chromosome Tethering and HIV-1 Replication*
- S. Emiliani, A. Mousnier, R. Benarous
- BiologyJournal of Biological Chemistry
- 8 July 2005
HIV-1 virus harboring a single mutation that disrupts integrase-LEDGF/p75 interaction, resulted in defective HIV-1 replication and it is found that LEDGF/ p75 tethers HIV- 1 integrase to chromosomes and that this interaction may be important for the integration process and the replication of HIV-2.
Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100
- E. De Clercq, N. Yamamoto, R. Datema
- BiologyAntimicrobial Agents and Chemotherapy
- 1 April 1994
The bicyclam JM3100, in which the cyclam moieties are tethered by an aromatic bridge, inhibits the replication of various HIV-1 and HIV-2 strains in various cell lines at a 50% effective concentration (EC50) of 1 to 10 ng/ml, which is about 100-fold lower than the concentration required for JM2763 to inhibit HIV replication and at least 100,000-fold higher than the cytotoxic concentration (> 500 micrograms/ml).
Preclinical Profile of BI 224436, a Novel HIV-1 Non-Catalytic-Site Integrase Inhibitor
- C. Fenwick, M. Amad, C. Yoakim
- Biology, ChemistryAntimicrobial Agents and Chemotherapy
- 24 March 2014
BI 224436 has drug-like in vitro absorption, distribution, metabolism, and excretion properties, including Caco-2 cell permeability, solubility, and low cytochrome P450 inhibition, and has an additive effect in combination with most approved antiretrovirals, including INSTIs.
Activity of non-nucleoside reverse transcriptase inhibitors against HIV-2 and SIV.
- M. Witvrouw, C. Pannecouque, K. Van Laethem, J. Desmyter, E. De Clercq, A. Vandamme
- Biology, ChemistryAIDS (London)
- 20 August 1999
The data demonstrate that NNRTI are not exclusively specific for HIV-1 but are also inhibitory to different HIV-2 and SIV strains.
Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360
- V. Fikkert, A. Hombrouck, M. Witvrouw
- BiologyAIDS (London)
- 21 October 2004
Integrase-chimeric virus technology confirmed that the integrase mutations are indeed fully responsible for the resistance phenotype of IIIB/S-1360res, the first HIV-1 integrase strand transfer inhibitor that has entered clinical development.
Antiviral activity against human immunodeficiency virus type 1 (HIV‐1) and type 2 (HIV‐2) of ethnobotanically selected Ethiopian medicinal plants
- K. Asres, F. Bucar, T. Kartnig, M. Witvrouw, C. Pannecouque, E. De Clercq
- ChemistryPhytotherapy Research
- 1 February 2001
Ethiopian medicinal plants used for the treatment of a variety of ailments including infectious diseases were screened for activity against human immunodeficiency virus type 1 and type 2 and polar extracts derived from 21 plants belonging to 14 families exhibited inhibition of viral growth at subtoxic concentrations.
Resistance of Human Immunodeficiency Virus Type 1 to the High-Mannose Binding Agents Cyanovirin N and Concanavalin A
- M. Witvrouw, V. Fikkert, A. Bolmstedt
- BiologyJournal of Virology
- 15 June 2005
Recombination of the mutated gp160 genes of the strains resistant to CV-N or ConA into a wild-type background fully reproduced the (cross-)resistance profiles of the originally selected strains, pointing to the impact of the N-glycan mutations on the phenotypic resistance profiles of both selected strains.
Activity of a Sulfated Polysaccharide Extracted from the Red Seaweed Aghardhiella Tenera against Human Immunodeficiency Virus and Other Enveloped Viruses
- M. Witvrouw, J. Esté, E. De Clercq
- Biology
- 1 October 1994
GS represents a natural polysaccharide with broad-spectrum activity against a number of important viral pathogens and proved active not only against HIV-1 and HIV-2 but also against other enveloped viruses, i.e. herpes-, toga-, arena-, myxo- and rhabdoviruses.
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