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Ribosomal Protein S6 Kinases, 70-kDa

Known as: p70 S6 Kinase, Ribosomal Protein S6 Kinases, 70 kDa, p70s6k 
A family of ribosomal protein S6 kinases that are considered the major physiological kinases for RIBOSOMAL PROTEIN S6. Unlike RIBOSOMAL PROTEIN S6… Expand
National Institutes of Health

Related topics

Related topics

10 relations
In BloodProcess of secretionRibosomal Protein S6 KinaseRibosomal Protein S6 Kinase Beta-1
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ribosomal protein S6 kinase, 70kD, polypeptide 2

Papers overview

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Highly Cited
2005
Highly Cited
2005
Ischemic preconditioning protects by activating prosurvival kinases at reperfusion.
Pharmacological activation of the prosurvival kinases Akt and ERK-1/2 at reperfusion, after a period of lethal ischemia, protects… Expand
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Highly Cited
2003
Highly Cited
2003
The Mammalian Target of Rapamycin (mTOR) Partner, Raptor, Binds the mTOR Substrates p70 S6 Kinase and 4E-BP1 through Their TOR Signaling (TOS) Motif*
The mammalian target of rapamycin (mTOR) controls multiple cellular functions in response to amino acids and growth factors, in… Expand
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Highly Cited
2002
Highly Cited
2002
Tuberin Regulates p70 S6 Kinase Activation and Ribosomal Protein S6 Phosphorylation
Although the cellular functions ofTSC2 and its protein product, tuberin, are not known, somatic mutations in the TSC2 tumor… Expand
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Highly Cited
2000
Highly Cited
2000
The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells
BACKGROUND Protein kinase B (PKB), and the p70 and p90 ribosomal S6 kinases (p70 S6 kinase and p90 Rsk, respectively), are… Expand
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Highly Cited
1999
Highly Cited
1999
Immunopurified Mammalian Target of Rapamycin Phosphorylates and Activates p70 S6 Kinase α in Vitro *
p70 S6 kinase α (p70α) is activated in vivo through a multisite phosphorylation in response to mitogens if a sufficient supply of… Expand
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Highly Cited
1998
Highly Cited
1998
Phosphorylation and activation of p70s6k by PDK1.
Activation of the protein p70s6k by mitogens leads to increased translation of a family of messenger RNAs that encode essential… Expand
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Highly Cited
1998
Highly Cited
1998
The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease
The Saccharomyces cerevisiae targets of rapamycin, TOR1 and TOR2, signal activation of cell growth in response to nutrient… Expand
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Highly Cited
1997
Highly Cited
1997
The Mitogenic and Myogenic Actions of Insulin-like Growth Factors Utilize Distinct Signaling Pathways*
It is well established that mitogens inhibit differentiation of skeletal muscle cells, but the insulin-like growth factors (IGFs… Expand
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Highly Cited
1994
Highly Cited
1994
Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins.
The immunosuppressant rapamycin (RAP) has been demonstrated to specifically inhibit the activity of p70 S6 kinase (p70s6k) and… Expand
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Highly Cited
1993
Highly Cited
1993
Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling.
The beta-isoform of glycogen synthase kinase-3 (GSK3 beta) isolated from rabbit skeletal muscle was inactivated 90-95% following… Expand
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