Ribosomal Protein S6 Kinases, 70-kDa

Known as: p70 S6 Kinase, Ribosomal Protein S6 Kinases, 70 kDa, p70s6k 
A family of ribosomal protein S6 kinases that are considered the major physiological kinases for RIBOSOMAL PROTEIN S6. Unlike RIBOSOMAL PROTEIN S6… (More)
National Institutes of Health

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In BloodProcess of secretionRibosomal Protein S6 KinaseRibosomal Protein S6 Kinase Beta-1
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ribosomal protein S6 kinase, 70kD, polypeptide 2

Papers overview

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Highly Cited
2006
Highly Cited
2006
Maximal lengthening contractions increase p70 S6 kinase phosphorylation in human skeletal muscle in the absence of nutritional supply.
The aim of this study was to compare the training stimuli of eccentric (lengthening) and concentric (shortening) contractions… (More)
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Highly Cited
2005
Highly Cited
2005
Ischemic preconditioning protects by activating prosurvival kinases at reperfusion.
Pharmacological activation of the prosurvival kinases Akt and ERK-1/2 at reperfusion, after a period of lethal ischemia, protects… (More)
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Highly Cited
2003
Highly Cited
2003
The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif.
The mammalian target of rapamycin (mTOR) controls multiple cellular functions in response to amino acids and growth factors, in… (More)
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Highly Cited
2002
Highly Cited
2002
Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM).
Although the cellular functions of TSC2 and its protein product, tuberin, are not known, somatic mutations in the TSC2 tumor… (More)
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Highly Cited
2000
Highly Cited
2000
The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells
BACKGROUND Protein kinase B (PKB), and the p70 and p90 ribosomal S6 kinases (p70 S6 kinase and p90 Rsk, respectively), are… (More)
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Highly Cited
2000
Highly Cited
2000
Stem cell factor/c-kit up-regulates cyclin D3 and promotes cell cycle progression via the phosphoinositide 3-kinase/p70 S6 kinase pathway in spermatogonia.
Stem cell factor (SCF)/c-kit plays an important role in the regulation of hematopoiesis, melanogenesis, and spermatogenesis. In… (More)
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Review
1996
Review
1996
p70 S6 kinase: an enigma with variations.
The S6 ribosomal protein is phosphorylated by p70 S6 kinase (p70S6k). Although the cellular role of S6 phosphorylation is still… (More)
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Highly Cited
1995
Highly Cited
1995
Control of p70 S6 kinase by kinase activity of FRAP in vivo
When complexed with the intracellular protein FKBP12, rapamycin is a potent immunosuppressant and an inhibitor of a mitogen… (More)
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Highly Cited
1994
Highly Cited
1994
Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins.
The immunosuppressant rapamycin (RAP) has been demonstrated to specifically inhibit the activity of p70 S6 kinase (p70s6k) and… (More)
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Highly Cited
1993
Highly Cited
1993
Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling.
The beta-isoform of glycogen synthase kinase-3 (GSK3 beta) isolated from rabbit skeletal muscle was inactivated 90-95% following… (More)
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