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Ribosomal Protein S6 Kinases, 70-kDa

Known as: p70 S6 Kinase, Ribosomal Protein S6 Kinases, 70 kDa, p70s6k 
A family of ribosomal protein S6 kinases that are considered the major physiological kinases for RIBOSOMAL PROTEIN S6. Unlike RIBOSOMAL PROTEIN S6… Expand
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
Pharmacological activation of the prosurvival kinases Akt and ERK-1/2 at reperfusion, after a period of lethal ischemia, protects… Expand
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Highly Cited
2003
Highly Cited
2003
The mammalian target of rapamycin (mTOR) controls multiple cellular functions in response to amino acids and growth factors, in… Expand
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Highly Cited
2002
Highly Cited
2002
Although the cellular functions ofTSC2 and its protein product, tuberin, are not known, somatic mutations in the TSC2 tumor… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Protein kinase B (PKB), and the p70 and p90 ribosomal S6 kinases (p70 S6 kinase and p90 Rsk, respectively), are… Expand
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Highly Cited
1999
Highly Cited
1999
p70 S6 kinase α (p70α) is activated in vivo through a multisite phosphorylation in response to mitogens if a sufficient supply of… Expand
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Highly Cited
1998
Highly Cited
1998
Activation of the protein p70s6k by mitogens leads to increased translation of a family of messenger RNAs that encode essential… Expand
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Highly Cited
1998
Highly Cited
1998
The Saccharomyces cerevisiae targets of rapamycin, TOR1 and TOR2, signal activation of cell growth in response to nutrient… Expand
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Highly Cited
1997
Highly Cited
1997
It is well established that mitogens inhibit differentiation of skeletal muscle cells, but the insulin-like growth factors (IGFs… Expand
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Highly Cited
1994
Highly Cited
1994
The immunosuppressant rapamycin (RAP) has been demonstrated to specifically inhibit the activity of p70 S6 kinase (p70s6k) and… Expand
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Highly Cited
1993
Highly Cited
1993
The beta-isoform of glycogen synthase kinase-3 (GSK3 beta) isolated from rabbit skeletal muscle was inactivated 90-95% following… Expand
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