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Ribosomal Protein S6 Kinases, 70-kDa

Known as: p70 S6 Kinase, Ribosomal Protein S6 Kinases, 70 kDa, p70s6k 
A family of ribosomal protein S6 kinases that are considered the major physiological kinases for RIBOSOMAL PROTEIN S6. Unlike RIBOSOMAL PROTEIN S6… 
National Institutes of Health

Related topics

Related topics

10 relations
In BloodProcess of secretionRibosomal Protein S6 KinaseRibosomal Protein S6 Kinase Beta-1

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ribosomal protein S6 kinase, 70kD, polypeptide 2

Papers overview

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Highly Cited
2004
Highly Cited
2004
Amino Acids and Insulin Control Autophagic Proteolysis through Different Signaling Pathways in Relation to mTOR in Isolated Rat Hepatocytes*
Autophagy, a major bulk proteolytic pathway, contributes to intracellular protein turnover, together with protein synthesis. Both… 
Highly Cited
2003
Highly Cited
2003
Time-restricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1
Mammalian target of rapamycin (mTOR) is a key regulator of translational capacity. The mTOR inhibitor rapamycin can prevent forms… 
Highly Cited
2001
Highly Cited
2001
Cyclic AMP Inhibits Akt Activity by Blocking the Membrane Localization of PDK1*
Akt is a protein serine/threonine kinase that plays an important role in the mitogenic responses of cells to variable stimuli… 
Highly Cited
2000
Highly Cited
2000
Insulin-like growth factor-I is an autocrine regulator of chromogranin A secretion and growth in human neuroendocrine tumor cells.
Carcinoid tumors are predominantly found in the gastrointestinal tract and are characterized by hypersecretion of various… 
Highly Cited
1998
Highly Cited
1998
Rapamycin Inhibition of the G1 to S Transition Is Mediated by Effects on Cyclin D1 mRNA and Protein Stability*
The immunosuppressant rapamycin has been shown previously to inhibit the G1/S transition in several cell types by prolonging the… 
Highly Cited
1998
Highly Cited
1998
Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity.
Here, we disrupted the p70 S6 kinase (p70(s6k)) gene in murine embryonic stem cells to determine the role of this kinase in cell… 
Highly Cited
1996
Highly Cited
1996
Rapamycin resistance tied to defective regulation of p27Kip1
The potent antiproliferative activity of the macrolide antibiotic rapamycin is known to involve binding of the drug to its… 
Highly Cited
1995
Highly Cited
1995
Comparison of the specificities of p70 S6 kinase and MAPKAP kinase‐1 identifies a relatively specific substrate for p70 S6 kinase: the N‐terminal kinase domain of MAPKAP kinase‐1 is essential for…
Highly Cited
1994
Highly Cited
1994
Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: An alternative route to mitogen-induced gene expression
Highly Cited
1992
Highly Cited
1992
Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide…
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