Small-molecule control of insulin and PDGF receptor signaling and the role of membrane attachment

  title={Small-molecule control of insulin and PDGF receptor signaling and the role of membrane attachment},
  author={Jian-xin Yang and K. Symes and M. Mercola and S. Schreiber},
  journal={Current Biology},
  • Jian-xin Yang, K. Symes, +1 author S. Schreiber
  • Published 1998
  • Biology, Medicine
  • Current Biology
  • BACKGROUND Receptor tyrosine kinases (RTKs) regulate the proliferation, differentiation and metabolism of cells, and play key roles in tissue repair, tumorigenesis and development. To facilitate the study of RTKs, we have made conditional alleles that encode monomeric forms of the normally heterotetrameric insulin receptor and monomeric platelet-derived growth factor (PDGF) beta receptors fused to the FK506-binding protein 12 (FKBP12). The chimeric receptors can be induced to undergo… CONTINUE READING
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