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Reverse Transcriptase Inhibitors
Known as:
Inhibitors, Reverse Transcriptase
, Viral Reverse Transcriptase Inhibitor
, Reverse Transcriptase Inhibitor
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Any substance that inhibits the activity of viral reverse transcriptase, an RNA-dependent DNA polymerase that transcribes viral RNA into DNA during…
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National Institutes of Health
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Related topics
Related topics
43 relations
Narrower (35)
2',3'-Dideoxynucleosides
Delavirdine
Didanosine
Dideoxynucleosides
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Broader (3)
Anti-HIV Agents
Antiviral Agents
Enzyme Inhibitors
HIV
In Blood
aspects of radiation effects
chemical synthesis
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Mutations in the connection domain of HIV-1 reverse transcriptase increase 3′-azido-3′-deoxythymidine resistance
G. Nikolenko
,
Krista A. Delviks-Frankenberry
,
+4 authors
V. Pathak
Proceedings of the National Academy of Sciences…
2007
Corpus ID: 33095312
We previously proposed that a balance between nucleotide excision and template RNA degradation plays an important role in…
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Highly Cited
2007
Highly Cited
2007
HIV-1 Reverse Transcriptase Plus-strand Initiation Exhibits Preferential Sensitivity to Non-nucleoside Reverse Transcriptase Inhibitors in Vitro*
J. Grobler
,
G. Dornadula
,
Michele R Rice
,
Amy L Simcoe
,
D. Hazuda
,
Michael D. Miller
Journal of Biological Chemistry
2007
Corpus ID: 8468864
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are highly specific and potent allosteric inhibitors of human…
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Highly Cited
2006
Highly Cited
2006
A high incidence of nucleoside reverse transcriptase inhibitor (NRTI)-induced lactic acidosis in HIV-infected patients in a South African context.
R. Geddes
,
S. Knight
,
M. S. Moosa
,
A. Reddi
,
K. Uebel
,
H. Sunpath
South African medical journal = Suid-Afrikaanse…
2006
Corpus ID: 29555973
OBJECTIVE To determine the incidence of and predisposing risk factors for lactic acidosis in HIV-infected patients on…
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Review
2003
Review
2003
HIV Resistance to Nevirapine and Other Non‐Nucleoside Reverse Transcriptase Inhibitors
M. Wainberg
Journal of Acquired Immune Deficiency Syndromes
2003
Corpus ID: 23608253
&NA; Nevirapine and other members of the non‐nucleoside reverse transcriptase inhibitor (NNRTI) family of anti‐HIV‐1 drugs are…
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Highly Cited
2002
Highly Cited
2002
ATP-Dependent Removal of Nucleoside Reverse Transcriptase Inhibitors by Human Immunodeficiency Virus Type 1 Reverse Transcriptase
L. Naeger
,
N. Margot
,
Michael D. Miller
Antimicrobial Agents and Chemotherapy
2002
Corpus ID: 24822418
ABSTRACT Removal of nucleoside chain terminator inhibitors mediated by human immunodeficiency virus (HIV) reverse transcriptase…
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Highly Cited
2001
Highly Cited
2001
Phenotypic hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in treatment-experienced HIV-infected patients: impact on virological response to efavirenz-based therapy
N. Shulman
,
A. Zolopa
,
+7 authors
J. Whitcomb
AIDS (London)
2001
Corpus ID: 36716523
BackgroundEnhanced susceptibility to non-nucleoside reverse transcriptase inhibitors (NNRTI) was recently described in…
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Review
1999
Review
1999
Transport, metabolism and elimination mechanisms of anti-HIV agents.
Li
,
Chan
Advanced Drug Delivery Reviews
1999
Corpus ID: 43173103
Highly Cited
1998
Highly Cited
1998
Patterns of Resistance and Cross-Resistance to Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors in Patients Treated with the Nonnucleoside Reverse Transcriptase Inhibitor Loviride
V. Miller
,
M. de Béthune
,
+5 authors
S. Staszewski
Antimicrobial Agents and Chemotherapy
1998
Corpus ID: 25301105
ABSTRACT Human immunodeficiency virus type 1 (HIV-1) strains resistant to nonnucleoside reverse transcriptase inhibitors (NNRTIs…
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Highly Cited
1995
Highly Cited
1995
A new series of pyridinone derivatives as potent non-nucleoside human immunodeficiency virus type 1 specific reverse transcriptase inhibitors.
V. Dollé
,
E. Fan
,
+6 authors
E. Bisagni
Journal of Medicinal Chemistry
1995
Corpus ID: 44581283
4-(Arylthio)-pyridin-2(1H)-ones variously substituted in their 3-, 5-, and 6-positions have been synthesized as a new series of 1…
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Highly Cited
1995
Highly Cited
1995
Preclinical evaluation of HBY 097, a new nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 replication
J. Kleim
,
R. Bender
,
+9 authors
G. Riess
Antimicrobial Agents and Chemotherapy
1995
Corpus ID: 39240879
HBY 097 [(S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3, 4-dihydroquinoxaline-2(1H)-thione] was selected from a series…
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