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Reverse Transcriptase Inhibitors

Known as: Inhibitors, Reverse Transcriptase, Viral Reverse Transcriptase Inhibitor, Reverse Transcriptase Inhibitor 
Any substance that inhibits the activity of viral reverse transcriptase, an RNA-dependent DNA polymerase that transcribes viral RNA into DNA during… 
National Institutes of Health

Related topics

Related topics

43 relations

Narrower (35)

2',3'-DideoxynucleosidesDelavirdineDidanosineDideoxynucleosides

Broader (3)

Anti-HIV AgentsAntiviral AgentsEnzyme Inhibitors
HIVIn Bloodaspects of radiation effectschemical synthesis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Mutations in the connection domain of HIV-1 reverse transcriptase increase 3′-azido-3′-deoxythymidine resistance
We previously proposed that a balance between nucleotide excision and template RNA degradation plays an important role in… 
Highly Cited
2007
Highly Cited
2007
HIV-1 Reverse Transcriptase Plus-strand Initiation Exhibits Preferential Sensitivity to Non-nucleoside Reverse Transcriptase Inhibitors in Vitro*
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are highly specific and potent allosteric inhibitors of human… 
Highly Cited
2006
Highly Cited
2006
A high incidence of nucleoside reverse transcriptase inhibitor (NRTI)-induced lactic acidosis in HIV-infected patients in a South African context.
OBJECTIVE To determine the incidence of and predisposing risk factors for lactic acidosis in HIV-infected patients on… 
Highly Cited
2002
Highly Cited
2002
ATP-Dependent Removal of Nucleoside Reverse Transcriptase Inhibitors by Human Immunodeficiency Virus Type 1 Reverse Transcriptase
ABSTRACT Removal of nucleoside chain terminator inhibitors mediated by human immunodeficiency virus (HIV) reverse transcriptase… 
Highly Cited
2002
Highly Cited
2002
Potency of Nonnucleoside Reverse Transcriptase Inhibitors (NNRTIs) Used in Combination with Other Human Immunodeficiency Virus NNRTIs, NRTIs, or Protease Inhibitors
ABSTRACT Efavirenz and a series of related quinazolinone nonnucleoside inhibitors of the human immunodeficiency virus type 1 (HIV… 
Highly Cited
2001
Highly Cited
2001
Phenotypic hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in treatment-experienced HIV-infected patients: impact on virological response to efavirenz-based therapy
BackgroundEnhanced susceptibility to non-nucleoside reverse transcriptase inhibitors (NNRTI) was recently described in… 
Review
1999
Review
1999
Transport, metabolism and elimination mechanisms of anti-HIV agents.
Highly Cited
1998
Highly Cited
1998
Patterns of Resistance and Cross-Resistance to Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors in Patients Treated with the Nonnucleoside Reverse Transcriptase Inhibitor Loviride
ABSTRACT Human immunodeficiency virus type 1 (HIV-1) strains resistant to nonnucleoside reverse transcriptase inhibitors (NNRTIs… 
Highly Cited
1995
Highly Cited
1995
A new series of pyridinone derivatives as potent non-nucleoside human immunodeficiency virus type 1 specific reverse transcriptase inhibitors.
4-(Arylthio)-pyridin-2(1H)-ones variously substituted in their 3-, 5-, and 6-positions have been synthesized as a new series of 1… 
Highly Cited
1995
Highly Cited
1995
Preclinical evaluation of HBY 097, a new nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 replication
HBY 097 [(S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3, 4-dihydroquinoxaline-2(1H)-thione] was selected from a series… 
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