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Reverse Transcriptase Inhibitors

Known as: Inhibitors, Reverse Transcriptase, Viral Reverse Transcriptase Inhibitor, Reverse Transcriptase Inhibitor 
Any substance that inhibits the activity of viral reverse transcriptase, an RNA-dependent DNA polymerase that transcribes viral RNA into DNA during… 
National Institutes of Health

Related topics

Related topics

43 relations

Narrower (35)

2',3'-DideoxynucleosidesDelavirdineDidanosineDideoxynucleosides

Broader (3)

Anti-HIV AgentsAntiviral AgentsEnzyme Inhibitors
HIVIn Bloodaspects of radiation effectschemical synthesis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Efficacy and tolerability of 3 nonnucleoside reverse transcriptase inhibitor-sparing antiretroviral regimens for treatment-naive volunteers infected with HIV-1: a randomized, controlled equivalence…
BACKGROUND Nonnucleoside reverse transcriptase inhibitor-based antiretroviral therapy is not suitable for all treatment-naive HIV… 
Highly Cited
2009
Highly Cited
2009
TMC278, a Next-Generation Nonnucleoside Reverse Transcriptase Inhibitor (NNRTI), Active against Wild-Type and NNRTI-Resistant HIV-1
ABSTRACT Nonnucleoside reverse transcriptase inhibitors (NNRTIs) have proven efficacy against human immunodeficiency virus type 1… 
Highly Cited
2009
Highly Cited
2009
The public health approach to identify antiretroviral therapy failure: high-level nucleoside reverse transcriptase inhibitor resistance among Malawians failing first-line antiretroviral therapy
Background:Over 150 000 Malawians have started antiretroviral therapy (ART), in which first-line therapy is stavudine/lamivudine… 
Review
2009
Review
2009
Virological monitoring and resistance to first-line highly active antiretroviral therapy in adults infected with HIV-1 treated under WHO guidelines: a systematic review and meta-analysis.
Review
2007
Review
2007
Adherence to Nonnucleoside Reverse Transcriptase InhibitorBased HIV Therapy and Virologic Outcomes
Context It is unclear whether HIV treatment regimens that contain nonnucleoside reverse transcriptase inhibitors (NNRTIs) require… 
Highly Cited
2007
Highly Cited
2007
Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: a phase II randomised controlled trial
Review
2001
Review
2001
Clinical Pharmacokinetics of Non-Nucleoside Reverse Transcriptase Inhibitors
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are a diverse group of compounds that induce allosteric changes in the… 
Highly Cited
2000
Highly Cited
2000
Inhibition of clinically relevant mutant variants of HIV-1 by quinazolinone non-nucleoside reverse transcriptase inhibitors.
A series of 4-alkenyl and 4-alkynyl-3, 4-dihydro-4-(trifluoromethyl)-2-(1H)-quinazolinones were found to be potent non-nucleoside… 
Highly Cited
1999
Highly Cited
1999
Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450.
Nevirapine (NVP), a non-nucleoside inhibitor of HIV-1 reverse transcriptase, is concomitantly administered to patients with a… 
Highly Cited
1991
Highly Cited
1991
Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors
Human immunodeficiency virus type 1 (HIV-1)-specific pyridinone reverse transcriptase (RT) inhibitors prevent HIV-1 replication… 
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