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Reverse Transcriptase Inhibitors

Known as: Inhibitors, Reverse Transcriptase, Viral Reverse Transcriptase Inhibitor, Reverse Transcriptase Inhibitor 
Any substance that inhibits the activity of viral reverse transcriptase, an RNA-dependent DNA polymerase that transcribes viral RNA into DNA during… 
National Institutes of Health

Related topics

Related topics

43 relations

Narrower (35)

2',3'-DideoxynucleosidesDelavirdineDidanosineDideoxynucleosides

Broader (3)

Anti-HIV AgentsAntiviral AgentsEnzyme Inhibitors
HIVIn Bloodaspects of radiation effectschemical synthesis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Simultaneous HPLC Determination of Efavirenz, 8-hydroxy Efavirenz, Neostigmine and Comparison of their Separation Using a C18 and Biphenyl Column through Pharmacological Evaluation
A simple, rapid and stable high performance liquid chromatography method for a combination of efavirenz, its major metabolite 8… 
2005
2005
Structure based activity prediction of HIV-1 reverse transcriptase inhibitors.
We have developed a fast and robust computational method for prediction of antiviral activity in automated de novo design of HIV… 
2004
2004
Exploring QSAR of Non-Nucleoside Reverse Transcriptase Inhibitors by Neural Networks: TIBO Derivatives
Abstract: Human Immunodeficiency Virus type 1 (HIV-1) reverse transcriptase is an important target for chemotherapeutic agents… 
2004
2004
Virological and immunological impact of non-nucleoside reverse transcriptase inhibitor withdrawal in HIV-infected patients with multiple treatment failures
No significant changes in viral load and CD4 cell count were observed 2-4 weeks after the withdrawal of non-nucleoside reverse… 
2003
2003
Comparison of metabolic abnormalities 48 weeks after switching from highly active antiretroviral therapy containing a non-nucleoside reverse transcriptase inhibitor to Trizivir versus continued…
Forty patients participating in the TRIZAL study were treated with a non-nucleoside reverse transcriptase inhibitor (NNRTI… 
2002
2002
Anti-HIV reverse transcriptase inhibitor
Infection with HIV-1 remains a global health problem and due to the emergence of drug-resistant HIV variants, there is an ongoing… 
2001
2001
Evidence for prolonged clinical benefit from initial combination antiretroviral therapy: Delta extended follow‐up
Background The findings from therapeutic trials in HIV infection with surrogate endpoints based on laboratory markers are only… 
1999
1999
Calanolide A: a natural non-nucleoside reverse transcriptase inhibitor.
Calanolide A, an experimental non-nucleoside reverse transcriptase inhibitor, is a synthetic version of a compound found in… 
Highly Cited
1995
Highly Cited
1995
Preclinical evaluation of HBY 097, a new nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 replication
HBY 097 [(S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3, 4-dihydroquinoxaline-2(1H)-thione] was selected from a series… 
1993
1993
Synthesis and evaluation of 2-pyridinone derivatives as specific HIV-1 reverse transcriptase inhibitors. 3. Pyridyl and phenyl analogs of 3-aminopyridin-2(1H)-one.
In an ongoing effort to develop novel nonnucleoside, specific human immunodeficiency virus type 1 (HIV-1) reverse transcriptase…