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Dideoxynucleosides

Known as: Dideoxynucleosides [Chemical/Ingredient], ddNus, dideoxynucleoside 
Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity… Expand
National Institutes of Health

Papers overview

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Review
2010
Review
2010
In the last 25 years, HIV-1, the retrovirus responsible for the acquired immunodeficiency syndrome (AIDS), has gone from being an… Expand
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Highly Cited
2002
Highly Cited
2002
OBJECTIVES Nucleoside reverse transcriptase inhibitors (NRTIs), particularly dideoxynucleoside analogs (ddNs), used in the… Expand
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Highly Cited
1999
Highly Cited
1999
Dideoxynucleosides, which are potent inhibitors of HIV reverse transcriptase and other viral DNA polymerases, are a common… Expand
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Highly Cited
1997
Highly Cited
1997
We describe a method for multiplex detection of mutations in which the solid-phase minisequencing principle is applied to an… Expand
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Highly Cited
1995
Highly Cited
1995
A set of mutations [Ala-62-->Val(A62V), V75I, F77L, F116Y, and Q151M] in the polymerase domain of reverse transcriptase (RT) of… Expand
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Review
1995
Review
1995
Severe and prolonged impairment of mitochondrial beta-oxidation leads to microvesicular steatosis, and, in severe forms, to liver… Expand
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Highly Cited
1991
Highly Cited
1991
The two thymidine (dThd) kinases in human cells, the cytosolic, S-phase-specific TK1 and the mitochondrial, constitutively… Expand
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Review
1989
Review
1989
THE development of a rational therapy against the etiologic agent of the acquired immunodeficiency syndrome (AIDS)1 2 3 was made… Expand
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Highly Cited
1988
Highly Cited
1988
Because of the probable role of HIV-infected monocyte/macrophages in the pathogenesis and progression of AIDS, it is essential… Expand
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Highly Cited
1985
Highly Cited
1985
A method for obtaining sequence information directly from plasmid DNA is presented. The procedure involves the rapid preparation… Expand
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