Dideoxynucleosides

Known as: Dideoxynucleosides [Chemical/Ingredient], ddNus, dideoxynucleoside 
Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity… (More)

Topic mentions per year

Topic mentions per year

1969-2017
010203019692017

Papers overview

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2002
2002
OBJECTIVES Nucleoside reverse transcriptase inhibitors (NRTIs), particularly dideoxynucleoside analogs (ddNs), used in the… (More)
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Highly Cited
1999
Highly Cited
1999
Dideoxynucleosides, which are potent inhibitors of HIV reverse transcriptase and other viral DNA polymerases, are a common… (More)
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1998
1998
Investigations were done to determine whether the replication kinetics of human immunodeficiency virus (HIV)-1 were altered when… (More)
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1997
1997
The in vitro effect of single or combined doses of zidovudine (AZT) and dideoxycytidine (ddC) on PHA-activated human peripheral… (More)
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1995
Highly Cited
1995
A set of mutations [Ala-62-->Val(A62V), V75I, F77L, F116Y, and Q151M] in the polymerase domain of reverse transcriptase (RT) of… (More)
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1994
1994
The effects of hydroxyurea (HU), an inhibitor of ribonucleotide reductase, on the replication of human immunodeficiency virus… (More)
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1991
Highly Cited
1991
The two thymidine (dThd) kinases in human cells, the cytosolic, S-phase-specific TK1 and the mitochondrial, constitutively… (More)
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Highly Cited
1989
Highly Cited
1989
To determine the effects of immunomodulatory agents upon HIV replication in macrophages, cultured monocyte-derived macrophages… (More)
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1988
1988
Because of the probable role of HIV-infected monocyte/macrophages in the pathogenesis and progression of AIDS, it is essential… (More)
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Highly Cited
1985
Highly Cited
1985
A method for obtaining sequence information directly from plasmid DNA is presented. The procedure involves the rapid preparation… (More)
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