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Delavirdine

Known as: Delavirdin, 1-(3-((1-Methylethyl)amino)-2-pyridinyl)-4-((5-((methylsulfonyl)amino)-1H-indol-2-yl)carbonyl)piperazine, Delavirdina 
A synthetic, non-nucleoside reverse transcriptase inhibitor. In combination with other anti-retroviral drugs, this agent has been shown to reduce HIV… 
National Institutes of Health

Related topics

Related topics

29 relations
Acquired Immunodeficiency SyndromeAlprazolamAstemizoleCisapride

Broader (5)

Anti-HIV AgentsAntiviral AgentsIndolesPiperazines

Narrower (2)

RescriptorU-90152

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Quantification of the HIV-integrase inhibitor raltegravir (MK-0518) in human plasma by high-performance liquid chromatography with fluorescence detection.
Highly Cited
2005
Highly Cited
2005
Cyclooxygenase-2 Is an Obligatory Factor in Methamphetamine-Induced Neurotoxicity
Methamphetamine causes persistent damage to dopamine nerve endings of the striatum. The mechanisms underlying its neurotoxicity… 
Highly Cited
2003
Highly Cited
2003
Simultaneous determination of nine antiretroviral compounds in human plasma using liquid chromatography.
Highly Cited
2001
Highly Cited
2001
Anti-HIV activity of aromatic and heterocyclic thiazolyl thiourea compounds.
2001
2001
Mismatched double-stranded RNA (polyI-polyC(12)U) is synergistic with multiple anti-HIV drugs and is active against drug-sensitive and drug-resistant HIV-1 in vitro.
Highly Cited
2000
Highly Cited
2000
Randomized study of saquinavir with ritonavir or nelfinavir together with delavirdine, adefovir, or both in human immunodeficiency virus-infected adults with virologic failure on indinavir: AIDS…
This study compared antiretroviral activity among 6 "salvage" therapy regimens. The study was a prospective, randomized, 2x3… 
2000
2000
Stereochemistry of halopyridyl and thiazolyl thiourea compounds is a major determinant of their potency as nonnucleoside inhibitors of HIV-1 reverse transcriptase.
Highly Cited
1999
Highly Cited
1999
The P236L Delavirdine-Resistant Human Immunodeficiency Virus Type 1 Mutant Is Replication Defective and Demonstrates Alterations in both RNA 5′-End- and DNA 3′-End-Directed RNase H Activities
ABSTRACT The nonnucleoside reverse transcriptase (RT) inhibitor (NNRTI) delavirdine (DLV) selects in vitro for the human… 
1999
1999
N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)] thiourea as a potent inhibitor of NNI-resistant and multidrug-resistant human immunodeficiency virus-1.
Highly Cited
1986
Highly Cited
1986
Resistance to anthrapyrazoles and anthracyclines in multidrug-resistant P388 murine leukemia cells: reversal by calcium blockers and calmodulin antagonists.
A series of anthrapyrazoles was examined for their cytotoxic effect on P388 cells resistant (P388R) to anthracyclines, N-[4-(9… 
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