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PAINFUL DIABETIC PERIPHERAL NEUROPATHY : A STEPWISE APPROACH TO TREATMENT
The stepwise approach to the treatment of painful diabetic peripheral neuropathy allows the practitioner to use a broad spectrum of therapeutic modalities and physiologic approaches to thisExpand
NAC: first controlled trial, positive results.
TLDR
The results of the first controlled trial on NAC (N-acetylcysteine) showed that NAC increases glutathione levels and possibly improves survival and showed NAC to be safe with no adverse effects attributed to the drug. Expand
Low vitamin B-12 blood levels associated with faster progression to AIDS.
TLDR
The almost twofold increase in progression to AIDS in those with low B-12 levels was found after adjusting for HIV-1-related symptoms, CD4+ cell count, age, serum albumin, use of antiretroviral therapy before AIDS, serum folate concentration, and frequency of alcohol consumption. Expand
Model AIDS program housed in African-American church.
: The Antioch Baptist Church in Cleveland, OH, opened an HIV testing, prevention, and referral center in April. Its founders hope that this program will become a national model for addressing theExpand
Drug-related neuropathy: low acetylcarnitine levels found.
: Persons with peripheral neuropathy induced by ddI, ddC, or d4T were found to have low levels of acetylcarnitine in their blood. The compound is known to be important in nerve functioning and inExpand
Saquinavir (Invirase): first protease inhibitor approved--reimbursement, information hotline numbers.
TLDR
Squinavir is the first protease inhibitor to be approved by the Food and Drug Administration for use in combination with one or more unspecified nucleoside analogs and has shown T-cell increases and viral load reductions similar to AZT when taken at the present low dosage. Expand
Marijuana safety study completed: weight gain, no safety problems.
No safety problems specific to HIV or protease inhibitors were found in a study in which volunteers stayed in a research hospital 24 hours a day and were randomly assigned to either smoke marijuana,Expand
Grapefruit juice and saquinavir.
: One problem with saquinavir is that it is poorly absorbed by the body because it is rapidly destroyed by cytochrome P456 3A4, a liver enzyme found in the intestinal wall. Studies show thatExpand
St. John's wort warning: do not combine with protease inhibitors, NNRTIs.
TLDR
St. John's wort, an herbal treatment for depression, should not be combined with certain drugs, including some antiretrovirals, following a study by the National Institutes of Health on dosing and blood levels of indinavir in HIV-negative test subjects. Expand
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