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Didanosine

Known as: 2,3-Dideoxyinosine, 2',3' Dideoxyinosine, 2'3' dideoxyinosine 
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the… 
National Institutes of Health

Related topics

Related topics

23 relations

Broader (4)

2',3'-DideoxynucleosidesAnti-HIV AgentsAntimetabolitesReverse Transcriptase Inhibitors
Acquired Immunodeficiency SyndromeDidanosine 10 MG/ML Oral Solution [Videx]Didanosine 125 MG Delayed Release Oral Capsule [Videx]Didanosine:ACnc:Pt:Ser/Plas:Qn

Narrower (2)

Videxscriptene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
In Vitro Evaluation of Hepatic Transporter-Mediated Clinical Drug-Drug Interactions: Hepatocyte Model Optimization and Retrospective Investigation
To assess the feasibility of using sandwich-cultured human hepatocytes (SCHHs) as a model to characterize transport kinetics for… 
Highly Cited
2004
Highly Cited
2004
DDI‐μFIA—A Readily Configurable Microarray‐Fluorescence Immunoassay Based on DNA‐Directed Immobilization of Proteins
We describe a chip‐based immunoassay for multiplex antigen detection, based on the self‐assembly of semi‐synthetic DNA–protein… 
Highly Cited
2004
Highly Cited
2004
A Loss of Viral Replicative Capacity Correlates with Altered DNA Polymerization Kinetics by the Human Immunodeficiency Virus Reverse Transcriptase Bearing the K65R and L74V Dideoxynucleoside…
Mechanisms governing viral replicative capacity are poorly understood at the biochemical level. Human immunodeficiency virus… 
Highly Cited
1997
Highly Cited
1997
Single-step kinetics of HIV-1 reverse transcriptase mutants responsible for virus resistance to nucleoside inhibitors zidovudine and 3-TC.
Two mutants of HIV-1 reverse transcriptase (RT) associated with high-level resistance of the virus to AZT (RT-AZT: D67N, K70R… 
Highly Cited
1996
Highly Cited
1996
Recognition of the highly conserved YMDD region in the human immunodeficiency virus type 1 reverse transcriptase by HLA-A2-restricted cytotoxic T lymphocytes from an asymptomatic long-term…
The human immunodeficiency virus (HIV) type 1 reverse transcriptase (RT) is an important target for therapeutic intervention and… 
Highly Cited
1995
Highly Cited
1995
K65R mutation of human immunodeficiency virus type 1 reverse transcriptase encodes cross-resistance to 9-(2-phosphonylmethoxyethyl)adenine
Cloned variants of human immunodeficiency virus type 1 that contain the K65R mutation in reverse transcriptase have previously… 
Highly Cited
1994
Highly Cited
1994
Mechanism of the inhibitory effect of curdlan sulfate on HIV-1 infection in vitro.
To study the mechanism by which sulfated polysaccharides with 1,3-beta-D-glucan as a main chain exert anti-HIV-1 activity, we… 
Review
1994
Review
1994
Physical activity, protein metabolism and protein requirements
The extent to which physical activity influences protein requirements is a difficult question to answer on two counts. First… 
Highly Cited
1992
Highly Cited
1992
Plasma HIV-1 viremia in HIV-1 infected individuals assessed by polymerase chain reaction.
We established a method to estimate the amounts of HIV-1 particles in plasma from patients with HIV-1 infection by using… 
Highly Cited
1972
Highly Cited
1972
Neuraminidase stimulates division and sugar uptake in density-inhibited cell cultures.
THE proliferation of normal cells stops when the cultures have formed confluent monolayers; this process is termed density… 
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