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Didanosine

Known as: 2,3-Dideoxyinosine, 2',3' Dideoxyinosine, 2'3' dideoxyinosine 
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the… 
National Institutes of Health

Related topics

Related topics

23 relations

Broader (4)

2',3'-DideoxynucleosidesAnti-HIV AgentsAntimetabolitesReverse Transcriptase Inhibitors
Acquired Immunodeficiency SyndromeDidanosine 10 MG/ML Oral Solution [Videx]Didanosine 125 MG Delayed Release Oral Capsule [Videx]Didanosine:ACnc:Pt:Ser/Plas:Qn

Narrower (2)

Videxscriptene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
Drug Absorption Interactions Between Oral Targeted Anticancer Agents and PPIs: Is pH‐Dependent Solubility the Achilles Heel of Targeted Therapy?
A majority of the novel orally administered, molecularly targeted anticancer therapies are weak bases that exhibit pH‐dependent… 
Review
2009
Review
2009
The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
Time-dependent inhibition (TDI) of cytochrome P450 (P450) enzymes caused by new molecular entities (NMEs) is of concern because… 
Highly Cited
2008
Highly Cited
2008
A Protracted and Dynamic Maturation Schedule Underlies Arabidopsis Leaf Development[W]
Leaf development has been monitored chiefly by following anatomical markers. Analysis of transcriptome dynamics during leaf… 
Highly Cited
2006
Highly Cited
2006
The Utility of in Vitro Cytochrome P450 Inhibition Data in the Prediction of Drug-Drug Interactions
The accuracy of in vitro inhibition parameters in scaling to in vivo drug-drug interactions (DDI) was examined for over 40 drugs… 
Highly Cited
2001
Highly Cited
2001
ARM Architecture Reference Manual
From the Publisher: This is the authoritative reference guide to the ARM RISC architecture. Produced by the architects that are… 
Highly Cited
2000
Highly Cited
2000
Dual-chamber pacing in the treatment of neurally mediated tilt-positive cardioinhibitory syncope : pacemaker versus no therapy: a multicenter randomized study. The Vasovagal Syncope International…
BACKGROUND-This study was performed to compare implantation of a DDI pacemaker with rate hysteresis with no implant in respect to… 
Highly Cited
1996
Highly Cited
1996
Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines
The ribonucleoprotein telomerase, a specialized cellular reverse transcriptase, synthesizes one strand of the telomeric DNA of… 
Highly Cited
1992
Highly Cited
1992
A controlled trial comparing continued zidovudine with didanosine in human immunodeficiency virus infection. The NIAID AIDS Clinical Trials Group.
BACKGROUND Although zidovudine is effective in patients with human immunodeficiency virus (HIV) infection, its efficacy may… 
Highly Cited
1989
Highly Cited
1989
In vivo activity against HIV and favorable toxicity profile of 2',3'-dideoxyinosine.
The purine analog 2',3'-dideoxyinosine (ddI), which has anti-retroviral activity in vitro was administered for up to 42 weeks to… 
Review
1986
Review
1986
The Natural History of Sick Sinus Syndrome
A literature review has addressed the two major factors in disease progression in sick sinus syndrome: atrioventricular block and… 
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