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Human Apolipoprotein B mRNA-editing Enzyme-catalytic Polypeptide-like 3G (APOBEC3G) Is Incorporated into HIV-1 Virions through Interactions with Viral and Nonviral RNAs*
TLDR
Interactions with viral proteins or viral genomic RNA are not essential for APOBEC3G incorporation and interactions with viral and nonviral RNAs that are packaged into viral particles are sufficient forAPOBec3G virion incorporation, according to a sensitive cytidine deamination assay. Expand
Human Immunodeficiency Virus Type 1 cDNAs Produced in the Presence of APOBEC3G Exhibit Defects in Plus-Strand DNA Transfer and Integration
TLDR
Wild-type A3G induced an additional fivefold decrease in the amount of viral DNA that was integrated into the host cell genome and similarly reduced the efficiency with which HIV-1 preintegration complexes (PICs) integrated into a target DNA in vitro. Expand
A single amino acid substitution in human APOBEC3G antiretroviral enzyme confers resistance to HIV-1 virion infectivity factor-induced depletion.
TLDR
It is found that a single amino acid substitution mutant of human APOBEC3G (D128K) can interact with HIV-1 Vif but is not depleted from cells; thus, it inhibits HIV- 1 replication in an HIV-2 Vif-resistant manner. Expand
Identification of Two Distinct Human Immunodeficiency Virus Type 1 Vif Determinants Critical for Interactions with Human APOBEC3G and APOBEC3F
TLDR
Two distinct Vif determinants are identified, amino acids Y40RHHY44 and D14RMR17, which are essential for binding to A3G and A3F, respectively, which could result in potent inhibition of HIV-1 replication by the APOBEC3 proteins. Expand
Recombinant Origin of the Retrovirus XMRV
TLDR
XMRV was not present in the original CWR22 tumor but was generated by recombination of two proviruses during tumor passaging in mice, suggesting that the association of XMRV with human disease is due to contamination of human samples with virus originating from this recombination event. Expand
Mutations in the connection domain of HIV-1 reverse transcriptase increase 3′-azido-3′-deoxythymidine resistance
TLDR
Results indicate that mutations in the C-terminal domain of RT significantly enhance clinical NRTI resistance and should be considered in genotypic and phenotypic drug resistance studies. Expand
Inhibition of Xenotropic Murine Leukemia Virus-Related Virus by APOBEC3 Proteins and Antiviral Drugs
TLDR
It is found that expression of A3G, A3F, or murine A3 in virus-producing cells resulted in their virion incorporation, inhibition of XMRV replication, and G-to-A hypermutation of the viral DNA with all three APOBEC3 proteins. Expand
Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: substitutions, frameshifts, and hypermutations.
  • V. Pathak, H. Temin
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 August 1990
TLDR
The in vivo forward mutation rate in a single replication cycle for spleen necrosis virus (SNV) is determined and hypermutants, which may arise through the action of an error-prone polymerase and could significantly contribute to the genetic variation in retroviral populations, are named. Expand
P Body-Associated Protein Mov10 Inhibits HIV-1 Replication at Multiple Stages
TLDR
The results show that Mov10 can potently inhibit HIV-1 replication at multiple stages and was efficiently incorporated into virions and reduced virus infectivity, in part by inhibiting reverse transcription. Expand
Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: deletions and deletions with insertions.
  • V. Pathak, H. Temin
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 August 1990
TLDR
Detailed analysis of two deletions with insertions indicates that these mutations occurred as a result of template switching during plus-strand DNA synthesis, and that fragments of viral RNA generated by the viral RNase H endonuclease are used as templates and contribute to the sequences inserted at the deletion junctions. Expand
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