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Regulator of G-Protein Signaling 4

Known as: RGP4, RGS4 
Regulator of G-protein signaling 4 (205 aa, ~23 kDa) is encoded by the human RGS4 gene. This protein is involved in the promotion of GTPase activity.
National Institutes of Health

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8 relations
G Protein-Coupled Receptor SignalingLigand BindingRGS DomainRGS4 gene
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Highly Cited
2005
Highly Cited
2005
The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators
The conjugation of arginine to proteins is a part of the N-end rule pathway of protein degradation. Three amino (N)-terminal… Expand
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Highly Cited
2001
Highly Cited
2001
Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia
Complex defects in neuronal signaling may underlie the dysfunctions that characterize schizophrenia. Using cDNA microarrays, we… Expand
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Highly Cited
1998
Highly Cited
1998
The N-terminal Domain of RGS4 Confers Receptor-selective Inhibition of G Protein Signaling*
Regulators of heterotrimeric G protein signaling (RGS) proteins are GTPase-activating proteins (GAPs) that accelerate GTP… Expand
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Highly Cited
1998
Highly Cited
1998
RGS4 Inhibits Signaling by Group I Metabotropic Glutamate Receptors
Metabotropic glutamate receptors (mGluRs) couple to heterotrimeric G-proteins and regulate cell excitability and synaptic… Expand
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Highly Cited
1997
Highly Cited
1997
Structure of RGS4 Bound to AlF4−-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis
RGS proteins are GTPase activators for heterotrimeric G proteins. We report here the 2.8 A resolution crystal structure of the… Expand
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Highly Cited
1997
Highly Cited
1997
RGS4 and GAIP are GTPase-activating proteins for Gq alpha and block activation of phospholipase C beta by gamma-thio-GTP-Gq alpha.
RGS proteins constitute a newly appreciated and large group of negative regulators of G protein signaling. Four members of the… Expand
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Highly Cited
1997
Highly Cited
1997
The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro.
Regulators of G protein signaling (RGS) proteins accelerate GTP hydrolysis by Gi but not by Gs class alpha-subunits. All RGS… Expand
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Highly Cited
1996
Highly Cited
1996
GAIP and RGS4 Are GTPase-Activating Proteins for the Gi Subfamily of G Protein α Subunits
Abstract A novel class of regulators of G protein signaling (RGS) proteins has been identified recently. Genetic evidence… Expand
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Highly Cited
1996
Highly Cited
1996
The GTPase-activating Protein RGS4 Stabilizes the Transition State for Nucleotide Hydrolysis*
RGS proteins constitute a newly appreciated group of negative regulators of G protein signaling. Discovered by genetic screens in… Expand
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Highly Cited
1996
Highly Cited
1996
GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits.
A novel class of regulators of G protein signaling (RGS) proteins has been identified recently. Genetic evidence suggests that… Expand
Is this relevant?
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