Regulator of G-Protein Signaling 4

Known as: RGP4, RGS4 
Regulator of G-protein signaling 4 (205 aa, ~23 kDa) is encoded by the human RGS4 gene. This protein is involved in the promotion of GTPase activity.
National Institutes of Health

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G Protein-Coupled Receptor SignalingLigand BindingRGS DomainRGS4 gene
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Papers overview

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2013
2013
Modification and functional inhibition of regulator of G-protein signaling 4 (RGS4) by 4-hydroxy-2-nonenal.
Oxidative stress has been implicated as a component of various pathologies including ischemia/reperfusion injury (IRI) and… (More)
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2010
2010
Allosteric inhibition of the regulator of G protein signaling-Galpha protein-protein interaction by CCG-4986.
Regulator of G protein signaling (RGS) proteins act to temporally modulate the activity of G protein subunits after G protein… (More)
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2010
2010
DHHC protein-dependent palmitoylation protects regulator of G-protein signaling 4 from proteasome degradation.
Regulator of G-protein signaling 4 (RGS4), an intracellular modulator of G-protein coupled receptor (GPCR)-mediated signaling, is… (More)
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2009
2009
Regulator of G protein signaling 4 confers selectivity to specific G proteins to modulate mu- and delta-opioid receptor signaling.
In vitro studies have shown that the Regulator of G protein Signaling 4 (RGS4) interacts with the C-termini of mu- and delta… (More)
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2008
2008
Identification of peptides that inhibit regulator of G protein signaling 4 function.
Regulators of G protein signaling (RGS) are a family of GTPase-activating proteins (GAP) that interact with heterotrimeric G… (More)
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2008
2008
Regulator of G-protein signaling subtype 4 mediates antihypertrophic effect of locally secreted natriuretic peptides in the heart.
BACKGROUND Mice lacking guanylyl cyclase-A (GC-A), a natriuretic peptide receptor, have pressure-independent cardiac hypertrophy… (More)
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Highly Cited
2001
Highly Cited
2001
Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia
Complex defects in neuronal signaling may underlie the dysfunctions that characterize schizophrenia. Using cDNA microarrays, we… (More)
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1997
1997
The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro.
Regulators of G protein signaling (RGS) proteins accelerate GTP hydrolysis by Gi but not by Gs class alpha-subunits. All RGS… (More)
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Highly Cited
1996
Highly Cited
1996
GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits.
A novel class of regulators of G protein signaling (RGS) proteins has been identified recently. Genetic evidence suggests that… (More)
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Highly Cited
1996
Highly Cited
1996
GAIP and RGS4 Are GTPase-Activating Proteins for the Gi Subfamily of G Protein α Subunits
terized G protein GAP is phospholipase C-b, which is Summary both a GAP for Gqa and the effector that is activated by that G… (More)
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