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Regulator of G-Protein Signaling 4

Known as: RGP4, RGS4 
Regulator of G-protein signaling 4 (205 aa, ~23 kDa) is encoded by the human RGS4 gene. This protein is involved in the promotion of GTPase activity.
National Institutes of Health

Related topics

Related topics

8 relations
G Protein-Coupled Receptor SignalingLigand BindingRGS DomainRGS4 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Mapping the regulator of G protein signaling 4 (RGS4): presynaptic and postsynaptic substrates for neuroregulation in prefrontal cortex.
Regulator of G protein signaling 4 (RGS4) regulates intracellular signaling via G proteins and is markedly reduced in the… 
2007
2007
Regulator of G-Protein Signaling 4 Interacts with Metabotropic Glutamate Receptor Subtype 5 in Rat Striatum: Relevance to Amphetamine Behavioral Sensitization
Regulator of G-protein signaling (RGS) 4 negatively modulates signaling of several Gαq-coupled receptors, including metabotropic… 
Highly Cited
2006
Highly Cited
2006
Selective interactions between G protein subunits and RGS4 with the C-terminal domains of the mu- and delta-opioid receptors regulate opioid receptor signaling.
2006
2006
Cellular stress increases RGS2 mRNA and decreases RGS4 mRNA levels in SH-SY5Y cells
Highly Cited
2004
Highly Cited
2004
Differentially Regulated Expression of Endogenous RGS4 and RGS7*
Regulators of G protein signaling (RGS proteins) constitute a family of newly appreciated components of G protein-mediated signal… 
2003
2003
Regulators of G-protein Signaling (RGS) 4, Insertion into Model Membranes and Inhibition of Activity by Phosphatidic Acid*
Regulators of G-protein signaling (RGS) proteins are critical for attenuating G protein-coupled signaling pathways. The membrane… 
2000
2000
NMR structure of free RGS4 reveals an induced conformational change upon binding Galpha.
Heterotrimeric guanine nucleotide-binding proteins (G-proteins) are transducers in many cellular transmembrane signaling systems… 
2000
2000
Rapid kinetics of regulator of G-protein signaling (RGS)-mediated Galphai and Galphao deactivation. Galpha specificity of RGS4 AND RGS7.
Regulator of G-protein signaling (RGS) proteins accelerate GTP hydrolysis by Galpha subunits speeding deactivation. Galpha… 
Highly Cited
1999
Highly Cited
1999
Solution structure of human GAIP (Galpha interacting protein): a regulator of G protein signaling.
The solution structure of the human protein GAIP (Galpha interacting protein), a regulator of G protein signaling, has been… 
1998
1998
Mutational Analysis of the Asn Residue Essential for RGS Protein Binding to G-proteins*
Members of the RGS family serve as GTPase-activating proteins (GAPs) for heterotrimeric G-proteins and negatively regulate… 
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