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Heterotrimeric G protein activation by G-protein-coupled receptors
Heterotrimeric G proteins have a crucial role as molecular switches in signal transduction pathways mediated by G-protein-coupled receptors. Extracellular stimuli activate these receptors, which thenExpand
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Insights into G protein structure, function, and regulation.
In multicellular organisms from Caenorhabditis elegans to Homo sapiens, the maintenance of homeostasis is dependent on the continual flow and processing of information through a complex network ofExpand
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The 2.0 Å crystal structure of a heterotrimeric G protein
The structure of a heterotrimeric G protein reveals the mechanism of the nucleotide-dependent engagement of the α and βγ subunits that regulates their interaction with receptor and effectorExpand
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The Many Faces of G Protein Signaling*
  • H. Hamm
  • Medicine, Biology
  • The Journal of Biological Chemistry
  • 9 January 1998
A large number of hormones, neurotransmitters, chemokines, local mediators, and sensory stimuli exert their effects on cells and organisms by binding to G protein-coupled receptors. More than aExpand
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Crystal structure of a G-protein beta gamma dimer at 2.1A resolution.
Many signalling cascades use seven-helical transmembrane receptors coupled to heterotrimeric G proteins (G alpha beta gamma) to convert extracellular signals into intracellular responses. UponExpand
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A Novel Bifunctional Phospholipase C That Is Regulated by Gα12 and Stimulates the Ras/Mitogen-activated Protein Kinase Pathway*
Three families of phospholipase C (PI-PLCβ, γ, and δ) are known to catalyze the hydrolysis of polyphosphoinositides such as phosphatidylinositol 4,5-bisphosphate (PIP2) to generate the secondExpand
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RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion
Parkinson disease is a neurodegenerative disorder whose symptoms are caused by the loss of dopaminergic neurons innervating the striatum. As striatal dopamine levels fall, striatal acetylcholineExpand
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Crystal structure of a GA protein βγdimer at 2.1 Å resolution
MANY signalling cascades use seven-helical transmembrane receptors coupled to heterotrimeric G proteins (Gαβγ) to convert extracellular signals into intracellular responses1. Upon nucleotide exchangeExpand
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Structural basis of function in heterotrimeric G proteins.
Heterotrimeric guanine-nucleotide-binding proteins (G proteins) act as molecular switches in signaling pathways by coupling the activation of heptahelical receptors at the cell surface toExpand
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The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S.
The 2.2 A crystal structure of activated rod transducin, Gt alpha.GTP gamma S, shows the bound GTP gamma S molecule occluded deep in a cleft between a domain structurally homologous to small GTPasesExpand
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