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Recombinant Interleukins

Known as: Interleukin, Interleukins, Recombinant Interleukin 
Formulated therapeutic analogs of one of a number of endogenous cytokine interleukins. Produced by T cells, macrophages, and other cells… 
National Institutes of Health

Related topics

Related topics

14 relations
Inhibition of Cell ProliferationInterleukin 1 alpha:MCnc:Pt:CSF:QnInterleukin 1 beta:MCnc:Pt:Ser/Plas:QnInterleukin 12:MCnc:Pt:Body fld:Qn:IA

Papers overview

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Highly Cited
2006
Highly Cited
2006
Mast cells are essential intermediaries in regulatory T-cell tolerance
Contrary to the proinflammatory role of mast cells in allergic disorders, the results obtained in this study establish that mast… 
Highly Cited
2000
Highly Cited
2000
High-dose recombinant interleukin-2 therapy in patients with metastatic melanoma: long-term survival update.
PURPOSE To update response duration and survival data for patients with metastatic melanoma receiving the high-dose IV bolus… 
Highly Cited
1996
Highly Cited
1996
A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells
A T helper type 1 (Th1)-mediated colitis with similarities to inflammatory bowel disease in humans developed in severe combined… 
Highly Cited
1995
Highly Cited
1995
Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.
The interleukin 2 receptor gamma chain (IL-2R gamma) is a component of the receptors for IL-2, IL-4, IL-7, and IL-15. Mutations… 
Highly Cited
1994
Highly Cited
1994
Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis…
OBJECTIVE To further define the safety and efficacy of recombinant human interleukin 1 receptor antagonist (rhIL-1ra) in the… 
Highly Cited
1994
Highly Cited
1994
CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3
Injection of anti-CD3 antibodies causes prompt expression of interleukin (IL)-4, IL-2, and interferon gamma (IFN-gamma) mRNA… 
Highly Cited
1990
Highly Cited
1990
Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4- producing cells
T cell populations derived from naive mice produce very small amounts of interleukin 4 (IL-4) in response to stimulation on anti… 
Highly Cited
1990
Highly Cited
1990
Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells.
A cytokine that can synergize with interleukin 2 to activate cytotoxic lymphocytes was purified to homogeneity. The protein… 
Highly Cited
1986
Highly Cited
1986
Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells.
The pathogenesis and progression of rheumatoid arthritis involves the production of biologically active lymphokines and monokines… 
Highly Cited
1985
Highly Cited
1985
Regression of established pulmonary metastases and subcutaneous tumor mediated by the systemic administration of high-dose recombinant interleukin 2
Incubation of resting lymphoid cells with recombinant interleukin 2 (IL- 2) in vitro leads to the generation of lymphokine… 
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