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Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial.
TLDR
Mechanical ventilation can induce a cytokine response that may be attenuated by a strategy to minimize overdistention and recruitment/derecruitment of the lung, and these physiological improvements are associated with improvements in clinical end points. Expand
CCR5 is characteristic of Th1 lymphocytes
TLDR
Two additional chemokine receptors, CCR5 and CXCR3, are studied in human, antigen-specific CD4+ Th1 and Th2 cell clones, which function in allergy and humoral immunity to parasites. Expand
Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial.
TLDR
Mechanical ventilation can induce a cytokine response that may be attenuated by a strategy to minimize overdistention and recruitment/derecruitment of the lung and whether these physiological improvements are associated with improvements in clinical end points should be determined. Expand
Adipose tissue is a major source of interleukin-1 receptor antagonist: upregulation in obesity and inflammation.
TLDR
It is demonstrated that WAT is one of the most important sources of IL-1Ra quantitatively, suggesting that this tissue could represent a novel target for anti-inflammatory treatment. Expand
High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interleukin-1, interferon, and elastase, in patients with adult respiratory distress syndrome after trauma, shock, or sepsis.
TLDR
Local release of TNF-alpha and IL-1 beta, possibly by pulmonary macrophages or other cells, and/or accumulation in the lung is associated with the development of ARDS. Expand
The Period Length of Fibroblast Circadian Gene Expression Varies Widely among Human Individuals
TLDR
A lentiviral circadian reporter is engineer that permits characterization of circadian rhythms in single skin biopsies and should permit quantitative trait mapping of human period length. Expand
Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL‐22 and IL‐17 production by human T helper cells
TLDR
The data provide compelling evidence that AHR activation participates in shaping human CD4+ T‐cell polarization favoring the emergence of a distinct subset of IL‐22‐producing cells that are independent from the Th17 lineage. Expand
Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts
TLDR
The ability of cachectin/TNF to stimulate collagenase and PGE2 production suggests that it may play a role in tissue destruction and remodelling, as these processes occur in inflammatory diseases. Expand
IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes.
TLDR
IL-10 has a potent and unique effect upon tissue macrophages and blood monocytes by enhancing TIMP-1 production while decreasing metalloproteinase biosynthesis. Expand
Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis.
TLDR
This review has summarized some of the evidence suggesting that cytokines may play an important role in mediating pathophysiologic events in RA and further understanding of cytokine inhibitors in the rheumatoid synovium may lead to the development of more specific and effective therapeutic agents. Expand
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