• Publications
  • Influence
Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation
It is revealed that a distinct process exists in which tissue macrophages undergo rapid in situ proliferation in order to increase population density, and expansion of innate cells necessary for pathogen control or wound repair can occur without recruitment of potentially tissue-destructive inflammatory cells. Expand
Lymphokine control of in vivo immunoglobulin isotype selection.
There is no direct evidence that IL-5 contributes to the generation of in vivo antibody responses, but two general conclusions may also be drawn. Expand
Cytokine regulation of host defense against parasitic gastrointestinal nematodes: lessons from studies with rodent models.
Studies with rodents infected with Trichinella spiralis, Heligmosomoides polygyrus, Nippostronglyus brasiliensis, and Trichuris muris have provided considerable information about immune mechanismsExpand
Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice
Data show that antigen-induced airway hyperresponsiveness and inflammation can be blocked by IL-12, which suppresses Th2 cytokine expression, which may provide a novel immunotherapy for the treatment of pulmonary allergic disorders such as atopic asthma. Expand
Interleukin‐4‐ and interleukin‐13‐mediated host protection against intestinal nematode parasites
It is argued that a limited ability of the host immune system to distinguish among different nematode parasites has led to the evolution of a stereotyped Th2 response that activates a set of effector mechanisms that protects against most intestinal nematodes parasites. Expand
IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis.
It is demonstrated that Stat6 signaling is not required for IL-4 enhancement of IgG1 production and actually inhibits IL- 4-induction of mucosal mastocytosis, and IL-13 may be more important thanIL-4 as an inducer of the Stat6 signaled signaling that leads to worm expulsion. Expand
Evidence for the involvement of interleukin 10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2
The results suggest that the anti-inflammatory effect of PGE2 on mononuclear phagocytes is mediated in part by an autocrine feedback mechanism involving IL-10, which is mimicked by agents that elevate intracellular levels of cAMP, but not cGMP. Expand
Pathways of anaphylaxis in the mouse.
Antigen-induced anaphylaxis in the mouse proceeds primarily through the IgG, FcgammaRIII, macrophage, and PAF pathway, even in an experimental model that is characterized by strong mast cell and IgE responses. Expand
Anaphylaxis: lessons from mouse models.
  • F. Finkelman
  • Medicine
  • The Journal of allergy and clinical immunology
  • 1 September 2007
Results of these studies suggest novel prophylactic agents, including nonstimulatory anti-IgE mAbs, IL-4 receptor antagonists, PAF antagonists, and agents that cross-link FcepsilonRI or FcgammaRIII to an ITIM-containing inhibitory receptor. Expand
Foxa2 regulates alveolarization and goblet cell hyperplasia
Analysis of lung tissue from patients with a variety of pulmonary diseases revealed a strong inverse correlation between FOXA2 and goblet cell hyperplasia, which indicates Foxa2 is required for alveolarization and regulates airway epithelial cell differentiation in the postnatal lung. Expand