Interleukin-10 and the interleukin-10 receptor.
- K. Moore, R. de Waal Malefyt, R. Coffman, A. O’Garra
- Biology, MedicineAnnual Review of Immunology
Findings that have advanced the understanding of IL-10 and its receptor are highlighted, as well as its in vivo function in health and disease.
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
- T. Mosmann, H. Cherwinski, M. Bond, M. Giedlin, R. Coffman
- Biology, MedicineJournal of Immunology
- 1 April 1986
A panel of antigen-specific mouse helper T cell clones was characterized according to patterns of lymphokine activity production, and two types of T cell were distinguished. Type 1 T helper cells…
TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.
Two types of cloned helper T cells are described, defined primarily by differences in the pattern of lymphokines ynthesized, and the different functions of the two types of cells and their lymphokine synthesis are discussed.
An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation
- C. Asseman, S. Mauze, M. Leach, R. Coffman, F. Powrie
- Biology, MedicineJournal of Experimental Medicine
- 4 October 1999
It is shown that interleukin (IL)-10 is an essential mediator of the regulatory functions of the CD45RBlow population, providing the first clear evidence that IL-10 plays a nonredundant role in the functioning of regulatory T cells that control inflammatory responses towards intestinal antigens.
Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus
An important role is shown for neutrophils in lupus pathogenesis, whereby neutrophil activated by anti-self antibodies release NETs, which contain antimicrobial peptides complexed with self-DNA and activate plasmacytoid dendritic cells, leading to interferon release and furtherment and aggravation of inflammation and disease.
Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
It is shown that mammalian DNA and RNA, in the form of ICs, are potent self-antigens for TLR9 and TLR7, respectively, and induce IFN-α production by PDCs, suggesting that TLRs may have a critical role in the promotion of lupus through the induction of IFn-α by P DCs.
Vaccine adjuvants: putting innate immunity to work.
Lymphokine control of in vivo immunoglobulin isotype selection.
There is no direct evidence that IL-5 contributes to the generation of in vivo antibody responses, but two general conclusions may also be drawn.
In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines
It is shown that a combination of the immunosuppressive drugs, vitamin D3 and Dexamethasone, induced human and mouse naive CD4+ T cells to differentiate in vitro into regulatory T cells, which produced only interleukin (IL)-10, but no IL-5 and interferon (IFN)-γ, and furthermore retained strong proliferative capacity.
Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists
The identification of the antigen recognition receptors for innate immunity, most notably the Toll-like receptors, has sparked great interest in therapeutic manipulation of the innate immune system and significant efforts have begun to develop antagonists to Toll- like receptors.