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Chemokines and chemokine receptors orchestrate cell migration and homing in the body. Humans have at least 44 chemokines that are… Expand PURPOSE
CC chemokine receptor 4 (CCR4) is expressed by peripheral T-cell lymphomas (PTCLs) and is associated with poor outcomes… Expand Purpose: Adult T-cell leukemia/lymphoma (ATLL) has a very poor prognosis. We have developed the humanized defucosylated anti–CC… Expand PurposeThere are no suitable small animal models to evaluate human antibody-dependent cellular cytotoxicity (ADCC) in vivo, due… Expand Chemokines are now known to play an important role in cancer growth and metastasis. Here we report that differentiating… Expand Human IgG1 antibodies with low fucose contents in their asparagine-linked oligosaccharides have been shown recently to exhibit… Expand We recently reported expression of the chemokine receptors CXC chemokine receptor 3 (CXCR3) and CC chemokine receptor 4 (CCR4) in… Expand BACKGROUND
T(H)2 cells and eosinophils selectively express CC chemokine receptor 4 and CCR3, respectively, and their chemokine… Expand Macrophage-derived chemokine (MDC) is a recently identified member of the CC chemokine family. MDC is not closely related to… Expand Thymus and activation-regulated chemokine (TARC) is a recently identified CC chemokine that is expressed constitutively in thymus… Expand