C-C Chemokine Receptor Type 4, human

Known as: CD194 Antigen, CCR4, CC Chemokine Receptor 4 
C-C chemokine receptor type 4 (360 aa, ~41 kDa) is encoded by the human CCR4 gene. This protein is involved in leukocyte chemotaxis.
National Institutes of Health

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Highly Cited
2009
Highly Cited
2009
Interleukin 22 (IL-22) is a cytokine produced by the TH-17 lineage of helper T cells and NK-22 subset of natural killer cells… (More)
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Highly Cited
2001
Highly Cited
2001
In vitro polarized human Th2 cells preferentially express the chemokine receptors CCR3, CCR4, and CCR8 and migrate to their… (More)
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Highly Cited
2001
Highly Cited
2001
Chemokines dictate regional trafficking of functionally distinct T cell subsets. In rodents and humans, a unique subset of CD4… (More)
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Highly Cited
2001
Highly Cited
2001
CCR4, a chemokine receptor for macrophage-derived chemokine (MDC) and thymus and activation-regulated chemokine (TARC), has been… (More)
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Highly Cited
2000
Highly Cited
2000
CC chemokine receptor (CCR)4, a high affinity receptor for the CC chemokines thymus and activation-regulated chemokine (TARC) and… (More)
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Highly Cited
2000
Highly Cited
2000
CCR4 is now known to be selectively expressed in Th2 cells. Since the bronchial epithelium is recognized as an important source… (More)
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Highly Cited
2000
Highly Cited
2000
Isolated peripheral blood CD4 cells from allergic individuals express CC chemokine receptor (CCR)3 and CCR4 after expansion in… (More)
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Highly Cited
1999
Highly Cited
1999
Lymphocytes that are responsible for regional (tissue-specific) immunity home from the blood to the intestines, inflamed skin or… (More)
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Highly Cited
1999
Highly Cited
1999
Helper T cells are classified into Th1 and Th2 subsets based on their profiles of cytokine production. Th1 cells are involved in… (More)
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Highly Cited
1997
Highly Cited
1997
Thymus and activation-regulated chemokine (TARC) is a recently identified CC chemokine that is expressed constitutively in thymus… (More)
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