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Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin.
TLDR
Antibodies present in pooled human intravenous immunoglobulins (IVIG) blocked Fas-mediated keratinocyte death in vitro and indicated that IVIG may be an effective treatment for toxic epidermal necrolysis of TEN. Expand
Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL‐22 and IL‐17 production by human T helper cells
TLDR
The data provide compelling evidence that AHR activation participates in shaping human CD4+ T‐cell polarization favoring the emergence of a distinct subset of IL‐22‐producing cells that are independent from the Th17 lineage. Expand
Peroxisome proliferator‐activated receptors in cutaneous biology
TLDR
Proprieties are pointing in the direction of PPARs being key regulators of skin conditions characterized by hyperproliferation, inflammatory infiltrates and aberrant differentiation such as psoriasis, but may also have clinical implications in inflammatory skin disease. Expand
Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus.
TLDR
The binding specificity of plakins for various IF proteins depends on their linker region between the highly homologous B and C subdomains and their COOH extremity and the association of DP and BP230 with both epidermal and simple keratins is critically affected by the tertiary structure induced by heterodimerization. Expand
Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily.
TLDR
Melatonin is identified as a ligand for the recently cloned orphan receptor retinoid Z receptor beta (RZR beta) and binding and activation of RZRbeta by melatonin with Kd and EC50 values in the low nanomolar range are shown. Expand
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) poisoning in Victor Yushchenko: identification and measurement of TCDD metabolites
TLDR
This case of poisoning with TCDD suggests that the design of methods for routine assessment ofTCDD metabolites in human beings should be a main aim of T CDD research in the metabolomic era. Expand
Pulse methylprednisolone therapy for severe alopecia areata: an open prospective study of 45 patients.
TLDR
A single series of intravenous pulse of methylprednisolone appears to be well tolerated and effective in patients with rapidly progressing extensive multifocal AA, but not those with ophiasic and universalis AA. Expand
A toxicological and dermatological assessment of aryl alkyl alcohols when used as fragrance ingredients.
TLDR
It is concluded that these materials would not present a safety concern at current levels of use as fragrance ingredients and the potential for photosensitization is low. Expand
Diagnosis and management of nail pigmentations.
TLDR
Using noninvasive techniques such as dermoscopy, one will be able to reduce the number of unnecessary surgeries and to choose the most adequate biopsy technique and propose a new algorithm for the non invasive diagnosis of nail pigmentation. Expand
Treatment of toxic epidermal necrolysis with high-dose intravenous immunoglobulins: multicenter retrospective analysis of 48 consecutive cases.
TLDR
Early infusion of high-dose IVIG is safe, well tolerated, and likely to be effective in improving the survival of patients with TEN. Expand
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